Have We Discussed This Before?

[bws]

YES! My dd does this too. Interesting.

[momcap]

YES! All 3 of my kids speak full blast. But they are all impulsive chatterboxes, so they have to yell over each other to be heard. There is NEVER a quiet moment in my house. Literally, NEVER! Besides talking all the time, they have no volume control. If their voice volume had a dial it would be 1 - whisper, 8 - normal (loud), and 10 - yelling. It's like 2-7 & 9 don't exist. No fine control whatsoever. This symptom, among others, had us looking at ASD for DS8 years ago. My husband is the same. If I can't hear him he will repeat at the exact same volume. I will say, "I still can't hear you, because you haven't changed your voice." Then he will yell, "WELL I DIDN'T WANT TO YELL AT YOU!" I ask if he could find a volume inbetween and he just looks confused, like that doesn't even make sense. Weird. I don't know if that's PANDAS. I'm the one, not DH that has a PANDAS-y past. But this is interesting.

[MomWithOCDSon]

Came across something interesting today during researching a completely different topic (zinc). Anyway, you have to love it when pieces of what appear to be discrepant puzzles seem to come together, so I thought I'd share.

 

So here's what seems to be coming from this discussion: loud talking = auditory processing discrepancy = processing differences frequently associated with PANDAS. Right?

 

Here's an abstract from a 1998 paper titled "Chemical anatomy of excitatory endings in the dorsal cochlear nucleus of the rat: differential synaptic distribution of aspartate aminotransferase, glutamate and vesicular zinc," by Rubio.

 

J Comp Neurol 1998 Sep 28;399(3):341-58

 

In order to identify cytochemical traits relevant to understanding excitatory neurotransmission in brainstem auditory nuclei, we have analyzed in the dorsal cochlear nucleus the synaptic distribution of aspartate aminotransferase, glutamate, and vesicular zinc, three molecules probably involved in different steps of excitatory glutamatergic signaling. High levels of glutamate immunolabeling were found in three classes of synaptic endings in the dorsal cochlear nucleus, as determined by quantitation of immunogold labeling. The first type included auditory nerve endings, the second were granule cell endings in the molecular layer, and the third very large endings, better described as "mossy." This finding points to a neurotransmitter role for glutamate in at least three synaptic populations in the dorsal cochlear nucleus. The same three types of endings enriched in glutamate immunoreactivity also contained histochemically detectable levels of aspartate aminotransferase activity, suggesting that this enzyme may be involved in the synaptic handling of glutamate in excitatory endings in the dorsal cochlear nucleus. There was also extrasynaptic localization of the enzyme. Zinc ions were localized exclusively in granule cell endings, as determined by a Danscher-selenite method, suggesting that this ion is involved in the operation of granule cell synapses in the dorsal cochlear nucleus.

 

Okay . . . I didn't know exactly what the dorsal cochlear nucleus is, so I looked that up, too: also known as the tuberculum acousticum, it is a cortex-like structure on the dorso-lateral surface of the brainstem. Along with the ventral cochlear nucleus, it forms the cochlear nucleus, where all auditory nerve fibers from the cochlea form their first synapses (Wikipedia).

 

So . . . my favorite "villan of the decade" . . . glutamate . . . may behind my Loud Talker, too! Must modulate glutamate, must modulate glutamate!

[bulldog24]

My brain hurts from reading that! Lol. This lyme brain cant process!!"

[little red]

So true for my daughter!