Leutolin

[LNN]

So I am at war with cytokines and have been searching for anti-inflammatory options other than ibuprofen or naproxen (Aleve). I came across these threads and was wondering if anyone had any experience with luteolin...

 

http://www.raysahelian.com/luteolin.html

Luteolin exerts a variety of pharmacological activities and anti-oxidant properties associated with its capacity to scavenge oxygen and nitrogen species. It also shows potent anti-inflammatory activities by inhibiting nuclear factor kappa B (NFkB) signaling in immune cells.

 

Luteolin and brain inflammation

University of Illinois researchers report lutelin, found in celery and green peppers, can disrupt a component of the inflammatory response in the brain. Rodney Johnson of the University of Illinois at Urbana-Champaign and graduate student Saebyeol Jang found that luteolin inhibits a key pathway in the inflammatory response of microglia -- brain cells key to the body's immune defense. Microglial cells exposed to luteolin show a significantly diminished inflammatory response. Luteolin reduces production of interleukin-6 -- used in cellular communication -- in the inflammatory pathway by as much as 90 percent.

 

My link

Luteolin is a yellow crystalline compound. It is a flavonoid; more specifically, it is one of the more common flavones.[1] From preliminary research, it is thought to play a role in the human body possibly as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune system modulator[citation needed]. If applicable to the human condition, these characteristics may inhibit cancer mechanisms. Basic research results indicate luteolin as an anti-inflammatory agent[2] with other potential effects on septic shock.[citation needed] It has been suggested for multiple sclerosis on the basis of in vitro work.[3]

 

and several pubmed studies (always makes me feel better when I can find these)

http://www.ncbi.nlm.nih.gov/pubmed/21671964

Significance and Impact of the Study:  The findings indicate that luteolin may be used as a basis for development of antimicrobial agents aimed at bacterial virulence factors.

 

http://www.ncbi.nlm.nih.gov/pubmed/21631167

ABSTRACT Microglia activation is one of the causative factors for neuroinflammation, which results in brain damage during neurodegenerative disease. Accumulating evidence has shown that the flavonoid luteolin (Lut) possesses potent anti-inflammatory properties; however, its effect on microglia inhibition is currently unknown. Moreover, it is not clear whether Lut also has indirect neuroprotective effects by reducing inflammatory mediators and suppressing microglia activation. In this study, we examined the effects of Lut on lipopolysaccharide (LPS)-induced proinflammatory mediator production and signaling pathways in murine BV2 microglia. In addition, we cocultured microglia and neurons to observe the indirect neuroprotective effects of Lut. Lut inhibited the LPS-stimulated expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β) as well as the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)). Moreover, Lut blocked LPS-induced nuclear factor kappa B (NF-κ activation. Preincubation of microglia with Lut diminished the neurotoxic effects, owing to the direct anti-inflammatory effects of the compound. Taken together, our findings suggest that Lut may have a potential therapeutic application in the treatment of neuroinflammatory disorders.

 

There's a site that sells the stuff as a lozenge or a powder - but I'm always hesitant to make my kids guinea pigs.

http://www.luteolin.com/

 

Anyone have any thoughts, pro or con? Will also post on the lyme forum...Any input appreciated.

Laura

[SSS]

Hi-

I just ordered the Lutimax supplement, in the pediatric poweder form.

There is a yahoo/lyme/austism board I lurk on- people are getting GREAT results with the Lutimax product.

It is only the leutolin in Lutimax, which I appreciate, as I don't want to add anything else.

Another board I lurk on has also posted VERY positive reviews with this product.

http://www.lutimax.net/

 

My dd6 has gut inflammation as well as the pandas inflammation, I am anxious to try this product.

Currently we are doing high EPA fish oil. I only use ibuprofen when really necessary.

[trggirl]

I don't know anything about Luteolin but I did want to tell you an experience we had which may or may not be related. B2 is also in the flavin family. My daughter was checked for vitamin deficiencies and she came back low on B2. We were given a bottle of B2 100mg to supplement. This was last fall and at this point my daughter was having strong and frequent tics and had been having them for about a month and a half. She would put her arms in the air over and over as if she had sleeves that were too long and she was trying to raise the sleeves. Anyway, I gave the B2 100mg and by day 2-3, the tics were completely gone. She also seemed to be way calmer. At that point, I realized I had made a mistake. I was only supposed to be giving her 25mg so I cut the dose immediately. She went on antibiotics soon after and the tics did not came back at that time. In January my daughter developed a body rash and I think I have tied it to the B2 so I stopped it , but the whole episode has stuck with me.

[MomWithOCDSon]

You're a research Queen, Laura! Thanks!

 

I'm interested to hear some more feedback on this, and I'm going to look into whether or not my local Vitamin Shoppe carries any luteolin supplements. I hear you on the whole "guinea pig" thing, but that research is pretty darn compelling!

[SSS]

You're a research Queen, Laura! Thanks!

 

I'm interested to hear some more feedback on this, and I'm going to look into whether or not my local Vitamin Shoppe carries any luteolin supplements. I hear you on the whole "guinea pig" thing, but that research is pretty darn compelling!

 

 

I know, I don't want guinea pig try outs either, but I am a bit desperate- we tried a product called Intestimend for the last 3-4 weeks, and while it beautifully reduced my dd6's gut inflammation, the ingredients gave us a huge yeast flair- pulled it, now back on an antifungal :-(

I will post how we do with the Lutimax- should be here today or tomorrow.

And, while the price was high on Lutimax, and part of me is loathe to 'buy something else' the parent testimony I read was VERY compelling.

Edited June 21, 2011 by S & S

[911RN]

You're a research Queen, Laura! Thanks!

 

I'm interested to hear some more feedback on this, and I'm going to look into whether or not my local Vitamin Shoppe carries any luteolin supplements. I hear you on the whole "guinea pig" thing, but that research is pretty darn compelling!

 

 

I know, I don't want guinea pig try outs either, but I am a bit desperate- we tried a product called Intestimend for the last 3-4 weeks, and while it beautifully reduced my dd6's gut inflammation, the ingredients gave us a huge yeast flair- pulled it, now back on an antifungal :-(

I will post how we do with the Lutimax- should be here today or tomorrow.

And, while the price was high on Lutimax, and part of me is loathe to 'buy something else' the parent testimony I read was VERY compelling.

 

 

 

There was research on the JNI site also- here is link:

 

http://www.jneuroinflammation.com/content/7/1/3

 

Many benefits for MS!!

[LNN]

Thanks for the feedback.

S&S - please let me know what results you see. Am seriously considering parting with some (more) money on this one.

 

On the lyme board, 911RN mentions that this supplement works best with a low-carb/high protein diet. As with her kids, carbs are a major part of my kids' diet and they'd rather starve than make a dramatic change. (we are limiting junk food, but with all they've been thru, all the pills they have to take, all the blood draws, pokes and prods, we pick our battles).

 

S&S - if you're back on the lyme/autism board and have contact with anyone currently using this, could you ask if the low carb aspect is essential?

[SSS]

Thanks for the feedback.

S&S - please let me know what results you see. Am seriously considering parting with some (more) money on this one.

 

On the lyme board, 911RN mentions that this supplement works best with a low-carb/high protein diet. As with her kids, carbs are a major part of my kids' diet and they'd rather starve than make a dramatic change. (we are limiting junk food, but with all they've been thru, all the pills they have to take, all the blood draws, pokes and prods, we pick our battles).

 

S&S - if you're back on the lyme/autism board and have contact with anyone currently using this, could you ask if the low carb aspect is essential?

 

 

LLM- of every parent review I read, not one said they were adhering to a lower carb diet. I will certainly keep you updated :-)

[rjayne]

Thanks for the feedback.

S&S - please let me know what results you see. Am seriously considering parting with some (more) money on this one.

 

On the lyme board, 911RN mentions that this supplement works best with a low-carb/high protein diet. As with her kids, carbs are a major part of my kids' diet and they'd rather starve than make a dramatic change. (we are limiting junk food, but with all they've been thru, all the pills they have to take, all the blood draws, pokes and prods, we pick our battles).

 

S&S - if you're back on the lyme/autism board and have contact with anyone currently using this, could you ask if the low carb aspect is essential?

 

 

LLM- of every parent review I read, not one said they were adhering to a lower carb diet. I will certainly keep you updated :-)

 

I had a nice talk with the "inventor" of lutimax and forked out the cash desperately hoping it would help with my daughter who has Opsoclonus myoclonus. The first day, the results were remarkable. She was doing things she had never done before (cleaning her room, helping around the house) cognitive fog lifted and she was using words I'd never heard her use, etc. Things took a drastic turn for the worse two days later. She became manic, couldn't stop talking and the tantrums were much worse than before the lutimax.

Such a disappointment, as the published research showed so much promise.

[SSS]

It didn't work out for us, either, my dd also became too hyper on it,

I added L-theanine (and in one formula they are mixed together) which did seem to cal

her down,

but seems like I saw an uptick in our vocal tics-

and I read something about how it affects dopamine?

I pulled it completely after 2 weeks.