Help with IgeneX results

[KaraD]

Hello all,

At the suggestion of this board, we did the IgeneX Western Blot with coinfections for ds, 4 who has suspected PANDAS. The results were as follows:

 

IgM

Band 41 IND

 

IgG

Band 39 IND

Band 41 ++ (I guess this is a 2+?)

 

Bartonella hensalae IgG 80 (interpretation says: may or may not indicate active infection. In pations with previously high titers, such titers indicate resolving infection)

 

Does this mean we need a LLMD or just to re-test?

 

Thanks,

Kara

[sf_mom]

I would see an LLMD due to Bartonella titers. You will need to minimally treat the Bartonella and continue to retest for Lyme as you proceed. My girlfriends son had similar results 'low titers for Bartonella, Ehrlichiosis and IND for Lyme'. He has been treated for Bartonella/Ehrlichiosis for 10 months now and doing tremendously well but has not yet fully resolved the Bartonella. His lyme results have not yet converted positive and they continue to retest for Lyme every three months. It is very rare to have Bartonella as a stand alone infection... typically only about 5% to 10% have only Bartonella. So more likely to have Lyme along with Bartonella. Rash can be present before treatment but often appear as herx..... as a result of treatment.

 

Does he have binding immune complexes? Immune deficiencies = weak antibody responder? Two other potential causes for the IND Lyme results.

 

You could also do provocation with antibiotics/herbs for the Urine PCR or Dot Blot to help determine if Lyme is present but you would need a good LLMD to prescribe for provocation.

 

Symptom List for Bartonella:

 

Aggression

Agitation

All Psychiatric disorders

Bartonella Causes over 200 Body Problems and Can Harm Any Organ

But Some Patients Have No Clear Symptoms

Confusion and Cognitive Troubles

Depression and Anxiety

Dizziness

Dozens of Types of Rashes

Drowsiness

Eye Disorders, e.g., Blurred Vision, Depth Perception, and Retinal Damage

Fainting

Fatigue

Headaches

Impulsivity

Irritability

Joint Pain

Kidney, Bladder, and Urogenital Disorders

Lumps in the Skin

Memory Problems

Migraines

Muscle Spasms and/or Weakness

Numbness or Loss of Sensation

Oxygen Deprivation

Panic Attacks

Physically or Verbally Violent behavior

Polyps in or on Major Organs

Profound Sensitivity to Medications

Sleep Disorders

Treatment Resistant Addictions and Compulsions

Tremors

Upper and Lower G.I. Tract Disorders

Edited April 18, 2011 by SF Mom

[KaraD]

Thanks for answering.

 

What are "binding immune complexes"?

 

He seems to be very autoimmune reactive based on his dietary IgG results and his PANDAS profile. . .would that rule out immune deficient?

 

I appreciate the help. I'm rather lost.

 

Kara

[sf_mom]

This is as simple as I can put it. Binding immune complexes are antigen-antibodies. It is their job to bind to a foreign proteins in the body i.e. bacteria and carry it off to the immune system for processing/elimination.

 

Technical answer. Scroll down until you see the Y shaped images and explanation.

 

http://www.google.com/imgres?imgurl=http://www.cartage.org.lb/en/themes/sciences/lifescience/generalbiology/physiology/LymphaticSystem/Antibodymediated/antigenAB.gif&imgrefurl=http://www.cartage.org.lb/en/themes/sciences/lifescience/generalbiology/physiology/LymphaticSystem/Antibodymediated/Antibodymediated.htm&h=303&w=454&sz=18&tbnid=Z6cypxnzUa8cXM:&tbnh=85&tbnw=128&prev=/search%3Fq%3Dantigen%25E2%2580%2593antibody%2Bcomplexes%26tbm%3Disch%26tbo%3Du&zoom=1&q=antigen–antibody+complexes&usg=__m1fbfftPrwTuD0o7KuPXQFMEjRw=&sa=X&ei=aZKtTbOTMKnKiALc74zNDA&ved=0CCgQ9QEwAQ

 

You can test to see if antigen-antibodies are present by testing for immune complexes. Again, if present often the antibodies are bound up to the antigen and can produce false negative on test result.

 

IgG subclasses are another test to see how the immune system is functioning. Here is an explanation also: http://www.immunedisease.com/patients-and-families/about-pi/types-of-pi/igg-subclass-deficiency.html

 

Who is your current PANDAS Dr? Regardless a good LLMD would be able to help you sort this all out and run additional confirmatory testing for Lyme if required. Minimally you need to treat the Bartonella.

 

-Wendy

Edited April 19, 2011 by SF Mom