Elevated ASO, low Dnase B - How to understand

[ange]

My son has pandas, and I think my duaghter may also be showing early signs. Her blood resluts were elevated ASO 320 (normal range was <150 for our lab) and low Dnase-B AB at <50 (ref range given for the lab was <187)

 

The doctor we are seeing for my son's pandas said the aso was nomal and dnase low, so she did not think it pointed at pandas. (This convo was via e-mail, she has not yet met my daughter and I wanted the bloods done first to see if I should schedule a consult $$$$)

 

However, I am questioning that - with the symptoms and high ASO (according to the ref. range), how significant is a low Dnase really?

 

Your thoughts...thanks.

 

Also, her eosinophils, absolute were elevated at 704 (range is 15-600) indicative of parasite infection or allergic reaction (she definitely has seasonal allergies in the spring, but that's all I know about). Any link here with the new behaviors (meltdowns, grumpiness, bossy/nasty to siblings).

[JAG10]

Ange,

 

Check out an older thread from Buster:

 

http://www.latitudes.org/forums/index.php?showtopic=7468&st=0&p=60702&hl=+%20+eosinophils&fromsearch=1entry60702

 

 

He was researching eosinophils absolute. Perhaps you could PM him to determine what he discovered?

 

How is your dd doing now?

 

Jill

[LNN]

My understanding is that the ASO rises in close proximity to a strep infection (1-3 weeks) and the Anti-DNase B rises/peaks in 4-6 weeks post-infection. So you may want to do another blood draw a month from now. It's the movement of the numbers, more than the absolute value, that is more telling.

 

But what I read between the lines is that this doctor would need convincing, which is something to consider when deciding who to pay for a consult and when. The high eosinophils could very well be allergy related, so re-checking once the trees were done blooming would give you a lot more information.

 

Your daughter's changes in mood could be Pandas, but it could also be allergies. My daughter becomes unbearable for a few weeks at this time of year and it's totally allergy related. Since you say your daughter's symptoms are relatively mild, I think your best bet is to do additional blood work over time to build your case or reassure yourself that numbers are trending down. With just one snapshot, mild symptoms and the height of allergy season, you may have a harder time convincing a doctor to take action than you might if you were to walk in with 3-6 months of data and a chart of correlating symptoms.

 

It's hard not to freak when a second child shows symptoms and you focus on trying to catch it early, but you may want to do additional blood work in a few weeks and in the meantime, introduce her to tools like CBT to help her control her moods/behaviors. If you want to post a few examples, we may be able to give you some ideas on what's worked with our kids.

 

Hang in there...