Hyper Immune System

[peglem]

Kimballot.. I read (and posted at the time) a good review article that said basically the same as you - that many folks produce auto-antibodies, it is part of a normal immune response but the issue is BBB breach. If no breach then no PANDAS....

 

I think this may be the reason for the "transient tics of childhood" thing. Isn't there is supposed to be some immune cells (T-cell type?) that kick in to destroy faulty antibodies that attack self tissue? If that were in working order, it would be transient. So perhaps, for some of our kids, its a malfunction in the "mop up" immune cells.

[dut]

I think this may be the reason for the "transient tics of childhood" thing. Isn't there is supposed to be some immune cells (T-cell type?) that kick in to destroy faulty antibodies that attack self tissue? If that were in working order, it would be transient. So perhaps, for some of our kids, its a malfunction in the "mop up" immune cells.

 

oohh - (don't want to flog a dead horse here but) would those t cells you mention be part of the innate system that gets shut off by chronic stealth infections like Lyme or mycoplasmas?

[kimballot]

Hi - we had our dd7's D8/17 marker tested in 2008 shortly after she presented with PANDAS symptoms. It was part of a PANDAS panel..(I think the company was either Immunosciences or Neuroimmunology.. can't remember) she came back elevated but.. shortly after I saw a talk by Swedo where she said they can no longer do D8/17 as the line is no longer available, so it threw the whole panel into doubt for me....

 

Kimballot.. I read (and posted at the time) a good review article that said basically the same as you - that many folks produce auto-antibodies, it is part of a normal immune response but the issue is BBB breach. If no breach then no PANDAS....

 

Thanks, dut - I will try to look for it. I probably read it and tucked it away in my brain but forgot where it came from! It does make sense to me.

 

Also - regarding the d8/17 test... I had read that something happened to stop the research, which is too bad because it could be a good test. But... it took 12 years to do a follow-up of the IVIG study... maybe there will be more interest in D8?17 in a few years!