So I got my husband's 23andme results and plugged it into genetic genie. My head is spinning. Just as a background, he was likely PANDAS as a child, has likely vaccine injury from the gulf war (13 or so vaccines before deployment) and recent rheumatic fever w/ regression into adult PANDAS like symptoms. He's in a much better place now, after long-term antibiotics.
his results--
MTHFR Homozygous (+/+) C677T mutation
Other mutations--
Homozygous (+/+) mutations:
· COMT V158M
· COMT H62H
· MAO-A R297R
· BHMT-02
· BHMT-04
· BHMT-08
· CBS A360A
Heterozygous (+/-) mutations:
· VDR Bsm
· VDR Taq
· MTR A2756G
· MTRR K350A
· AHCY-01
· AHCY-02
· AHCY-19
· SHMT1 C1420T
I honestly don't know where to begin. He pretty much has defects throughout his methylation pathway. I gather from my brief reading that he won't tolerate methyl donors well, so hydroxy B12 better? Is methylfolate still ok? I know he needs folate b/c he has high homocysteine levels. No need for anyone to reply I'm just thinking/planning out loud.