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Hi Everyone, Has anyone used D Mannose successfully for urinary urgency, dribbling, discomfort and a negative urine culture. My theory is that for some, when you go on antibiotics/herbals, the bacteria(all kinds as well as tick related coinfections) like to congregate in the warm moist bladder and cause irritation. I have seen this pattern before when we first started on antibiotic treatment and it triggered urinary urgency, dribbling, and discomfort that lasted several months and now again, we are seeing these issues after switching to herbals. Another theory I have is that they cling to bladder lining which is why some get repeated negative urine culture. Been there, done this as well. In my searching of the forum, I did see one or two comment on D Mannose as helping. Nothing recent. I also hope that since the D Mannose is absorbed quickly and shunted mostly thorugh the urinary system, it will not cause any gut growth of bacteria since it is techincally a sugar. I would imagine that other lyme/IC sufferers reporting relief would also have leaky guts and they are not complaining of bacterial growth in intestine afte rusing D mannose. Finally, in my searching, I am coming across something called mannose binding lectin deficiency .....big sigh....seems like several of the kids on this forum are coming up with this as well. Will be researching this now. Thanks for any input on the above. Kim