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Hi - new here! After at least four years of an unbearable situation, including a psych. hospitalization and 2 years away, our ds14 finally moved back home in March, when we started PANS treatment. Better late than never. We are continuing to stabilize him and on the whole things are improving under the care of our PANS MD/NP in N.CA. We are treating integratively and weaning ds14 off of many of some of his psychopharms. However, we have had four acute flares that look like manic episodes alternating between euphoria and aggression. To the point where our Crisis Team has had to come and we were deciding whether to call 911 and request a 5150. UGH. We continue to work on what is causing the flares but in the meantime, the episodes are so acute that we need to safely sedate him at home (I know, terrible), which is essentially what the psych hospital will do, and worse. 1) Any experience with meds to quell an episode in the moment? Benadryl or Atarax used to work, so I'm assuming he has high histamine. Ativan or any benzos cause a paradoxical reaction. 2) Anyone done Cytochrome P450 testing through YourScrip in Seattle, WA? Thanks so much.