That's the $64,000 question. My son got strep this summer while on treatment dose Augmentin and Biaxin. A round of Keflex cleared it up. His allergist was shocked. Enough so that he ordered some immune testing. IgA, IgE, IgM and IgG and subclasses. IgA turned up to be slightly low. We are now watching that. Titers were checked for diphtheria and tetanus and both came back in the post vaccination range, so his immune system is functioning and has made antibodies to vaccinations that he had long ago. He's nearly 11.