June 17, 2004
I will try to answer each question. Please understand I am not a physician, I do not treat patients. I am an independent clinical laboratory that has been doing kryptoyrrole testing since the mid-1970's. I am a Medical Technologist, I personally run the procedure and treat each specimen as if it was my own.
I will answer your questions with information I have read.
Literature indicates most persons have less than 10 mcg of Kryptopyrrole per deciliter. Persons with 10-20 are considered "borderline" pyroluric and may benefit from treatment depending on their clinical symptoms. Persons with levels above 20 mcg/dl are considered to have pyroluria, especially if symptoms are present.
To make an initial diagnosis, no vitamins or minerals should be taken two days before the urine is collected.
According to Natural Healing for Schizophrenia and other common mental disorders by Eva Edelman Forwarded by Abram Hoffer, M.D., PhD.
Pyroluria is characterized by excess urinary Kryptopyrrole. *Kryptopyrrole binds irreversibly with B6. The resulting compound combines with any available zinc, and is excreted in the urine, thus severely depleting the body of both B6 and zinc.
Zinc is required in the development of nerves, nucleus formation, and collagen and protein synthesis. It promotes resistance to stress and disease, supports thyroid and insulin activity,as well as intellectual functioning, helps moderate moods, and benefits some types of headaches. With manganes, zinc chelates copper and supports histamine storage. Zinc also maintains the senses of taste and smell. Deficiency has been associated with paranoia, memory problems, irritability, behavior disorder, joint pain, immune dysfunction and carbohydrate intolerance.
Manganese is necessary for blood sugar regulation, sugar and protein metabolism, joint and cartilage development, prevention of autoimmune disorders and allergies, bone growth, thyroid function, and the moderation of depression. It makes choline available to form the neurotransmitter acetylcholine, needed to conduct impulses between nerves and muscles and important in memory function. Manganese deficiency has been associated with fatigue, dizziness, glucose intolerance, joint malformation, seizures and incoordination.
Vitamin B-6 is used in cerebral detoxification; the metabolism of carbohydrates, fats and all amino acids; and in RNA and DNA synthesis. B6 supports formation of a number of important neurotransmitters, including serotonin, dopamine, norepinephrine, acetycholine and GABA. B6 also supports the thyroid, helps maintain immune functioning, and is essential to hemoglobin and steroid synthesis. Deficiency can induce nausea, tingling shock-like sensations in the limbs., and childhood convulsions. B6 has been used in treating hyeractivity, epilepsy, depression, agitation, autism, cerebral allergies, childhood schizophreniz, pyroluria and histamine imbalances.
Treatment, focuses on vitaminn B6, zinc and manganese. According to Pfeiffer, pyroluria is easily treatable and patient improvement is directly related to the reduction in urinary kryptopyrrole. Pyrolurics often respond to nutritional treatment within one to seven days, and may totally recover within three to four months, barring confounding conditions, e.g. heavy metal toxicity or a histamine imbalance.
Nutrient treatment should be maintained, and increased when undergoing stress, to avoid relapse. If zinc and B6 supplementation is discontinued, a rapid return of serious symptoms usually occurs within two days to two weeks.
IMPORTANT
SUPPLEMENTATION NEEDS TO BE DIRECTED BY A DOCTOR AS TOO MUCH CAN BE TOXIC, USE OF THE WRONG FORM WILL BE INEFFECTIVE AND AVOIDING COMPETING MINERALS AND SUPPLEMENTS MAY BE NECESSARY.
Links to related studies
www.hriptc.org or 630-505-0300
------------------------------------------------------------------------------------------------
Clarification
Urinary Kryptopyrrole measurments are used to diagnose pyroluria, along with physical examination to observe the patient for physical signs of pyroluria, and a medical history to evalute symptoms of pyroluria.
Maybe Claire referred to it as pyrollia in error
Yes we do the test Kryptopyrrole for pyroluria. Pyroluria is characterized by an increase in urinary Kryptopyrrole.
Honestly I don't know what procedure BioCenter lab is running so I can't comment on their form as you indicate they call it urinary pyrolles
I don't understand the Omega 3s & 6s mix up. If you could clarify I could try to get you an answer.
Kryptopyrrole Specimen Collection Requirements
The specimen container has a preservative of ascorbic acid.
The specimen is sensitive to light. My directions require the specimen be immediately frozen upon collection. Therefore, by placing the specimen in the freezer it is not exposed to light. When it is removed from the freezer and put in the styrofoam kit again there is little to no light exposure. So I don't find the light a issue, because the directions, if followed, do not expose the specimen to light.
Freezing is critical and keeping that specimen frozen is critical. I don't care what any other lab is doing. I know that studies performed in our laboratory determined that specimens received not frozen "average" 27% lower than frozen specimens. I do know I was very curious about BioCenter lab so I split two specimens one I ran here and one I sent to BioCenter Lab following there directions, my result was 12.0 there results was 2. So I really don't want to comment on any other laboratory expect mine.
I hope I have answered your questions.
Wishing all of you a great day.
Respectfully,
Ellen Hanson