Hi ,
This is the article I found on melatonin and TS. Check out the last sentence. My son has ADD and a movement disorder called shudderring attacks since infancy with a new onset of tics which began 2 weeks after starting the melatonin (which by the way worked beautifully for sleep). He has been taking Concerta 27mg. for 3 years with great results except the rebound and insomnia. I suspect he may have TS but of course the MD wants him off stimulants and said we'll see. It may resolve quickly or take months or not at all. I realize the likelyhood of TS is high given the comorbidity of other issues. He is sniffing his fingers alot and it looks so uncomfortable, my heart breaks for him.
The relationship of pineal calcification and melatonin secretion to the
pathophysiology of tardive dyskinesia and Tourette's syndrome.
Sandyk R, Kay SR.
Department of Psychiatry, Albert Einstein College of Medicine/Montefiore
Medical Center, Bronx, NY 10461.
Despite current intensive research, the pathophysiology of tardive
dyskinesia (TD), a serious neurological side effect of neuroleptic
treatment, is poorly understood. Prompted by the observation of an
increased incidence and severity of abnormal perioral movements in
neuroleptic-treated pinealectomized, as compared to intact rats, we
suggested that the pineal gland exerts a protective effect which mitigates
against the development of TD and, by inference, that reduced melatonin
secretion may be related to the pathophysiology of TD. To investigate this
proposition further, we studied the association of TD with pineal
calcification (PC) on CT scan in chronic schizophrenic patients. Our
findings revealed a significant association between TD and PC and suggest,
furthermore, that PC may be a neuroradiological marker of TD. Since PC may
reflect diminished secretory activity of the gland, these findings support
the hypothesis that the pathophysiology of TD is linked to disturbances of
melatonin secretion. The clinical and therapeutic implications of these
novel findings are discussed. In the following communication, in which we
introduce the hypothesis that disturbances of 5-HT and melatonin secretion
are related to the pathophysiology of TD. Subsequently, we present a series
of studies which relate to the association of TD with PC. We conclude by
presenting the hypothesis that disturbances in melatonin secretion may also
be relevant to the pathophysiology of Tourette's syndrome.
Publication Types:
· Case Reports
· Clinical Trial
· Randomized Controlled Trial
· Review
· Review, Tutorial
PMID: 1365044 [PubMed]