Just started it this weekend and seeing improvement in all 3 of my kids, but the it is most apparent in my most severely affected DS. The irritability is almost gone and he can even tell me that he feels less anxious. Very low dose, 5 drops in a capsule. His PANDAS psychiatrist was open to us trying it. I used Bluebird brand, based on another parent's posting in this forum because I had no idea which companies were more reputable. Now I am just trying to figure out what time to give the second dose, as it doesn't last the whole day.