From what I understand, if you have high histamine (due to MTHFR) you need to completely avoid folic acid/synthetic B vitamins and supplement with methylfolate and methylcobalamin. Also, there are two different vitamin K's to consider. Vitamin K1 comes from vegetables, vitamin K2 is derived from bacteria in the gut and animal fat.
Vitamin K2 deficiency has been implicated as a cause of autism.