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Yes, I found out about the B-6 blood clot thing while researching DVT and Air travel. Here is the article: Vitamin B6 and "economy class syndrome" MILANO, ITALY. Blood clots in the legs (deep-vein thrombosis) are a major cause of pulmonary embolism – a condition in which a blood clot lodges in the pulmonary artery. Pulmonary embolism is a very serious disorder that kills about 200,000 American every year. One of the main causes of vein thrombosis is immobilization, that is, lying or sitting still for extended periods of time. The condition is often found in hospitalized patients and, to an increasing degree, in long-distance air travel passengers particularly those crammed into economy class; hence the term "economy class syndrome". Several studies have shown that deep-vein thrombosis (DVT) is associated with a high blood level of homocysteine, a sulfur-containing amino acid also implicated in the development of atherosclerosis. Researchers at the University of Milano now confirm this connection with a new study that also clearly shows the potential protective effect of vitamin B6 (pyridoxine). The researchers compared blood levels of homocysteine, folic acid, vitamin B6, and vitamin B12 in 397 patients with previous DVT and 585 matched healthy controls. After adjusting for confounding variables they determined that the incidence of DVT was twice as high among the participants with high homocysteine levels as among those with lower levels. There was no association between DVT incidence and blood levels of folic acid and vitamin-B12. The association between low levels of vitamin B6 and an increased risk of DVT was, however, quite strong. The participants with low vitamin B6 levels (less than 33.2 nanomol/L of pyridoxal-5'-phosphate[PLP]) had twice the risk of developing DVT than did people with PLP levels above 46.5 nanomol/L. The researchers point out that vitamin-B6 supplementation has been found to inhibit platelet aggregation and prolong bleeding time as well as protecting against heart attacks and atherosclerosis. Further studies are underway to determine if vitamin B6 supplementation can help prevent DVT. Cattaneo, M., et al. Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis. Circulation, Vol. 104, November 13, 2001, pp. 2442-46

My family has pyroluria and one side effect of the condition is blood clots. Studies have shown blood clots to be related to B6 defficiencies. I have survived a pulmonary embolism and have been on a health quest ever since. Four members of my family have had some type of blood clotting issues. For the past year, visits to a doctor that does live blood analysis have shown severe plattelete aggregration (red blood cells sticking together) along with a host of other problems including digestion and physical stress. After adopting the recommended pyroluria therapy on another web page, my latest live blood analysis was perfect. The doctor told me with blood like that, there's no worries about blood clots and I didn't need to come back for another visit. I'm am so happy that I don't have to be on coumadin for the rest of my life as the side effects of that treatment are pretty severe. The supplements I take daily are as follows: Waking Solgar megasorb B-complex "50" 1 tablet North American Herb and Spice Purely C 2 capsules (whole food source of vitamin C) Zinc gluconate (seems to work best) 50 mg. Manganese gluconate 50 mg. Udos choice enzyme blend 1 capsule NOW N-Acetyl Cysteine (NAC) 1 capsule Solgar P-5-P 50 mg. Solgar Magnesium Citrate 200 mg. Nature's Plus children's chewable multi vitamin (low dosage seems better) Mid Morning North American Herb and Spice Purely C 2 capsules Zinc gluconate (seems to work best) 50 mg Udos choice enzyme blend 1 capsule Now NAC 1 capsule Solgar P-5-P 50 mg. Solgar B6 50 mg. Solgar Magnesium Citrate 200 mg. Lunch Udos choice enzyme blend 2 capsules Mid Afternoon North American Herb and Spice Purely C 2 capsules Udos choice enzyme blend 1 capsule Now NAC 1 capsule Solgar P-5-P 50 mg. Solgar B6 50 mg. Solgar Magnesium Citrate 200 mg. Dinner Udos choice enzyme blend 2 capsules Bedtime Kyo-Dophilus 1 capsule organic aloe vera juice 2 oz. I feel better than I did in my twenties. I am still experimenting with the NAC since this is the first one I've tried but it seems to work pretty well. Hopefully this will help someone else avoid the long search I have been on to feel better.