Lyme disease and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). An overview.
Editor: We have an excellent forum on our website for Lyme disease and its overlap with symptoms of PANDAS, tics and Tourettes, OCD and other related disorders. Please see the forum here. A technical study report focusing on the immune system and its connection with Lyme and PANDAS was published in the International Journal of General Medicine. Here’s the abstract:
Lyme disease (LD) is a complex, multisystemic illness. As the most common vector- borne disease in the United States, LD is caused by bacterial spirochete Borrelia burgdorferi sensu stricto, with potential coinfections from agents of anaplasmosis, babesiosis, and ehrlichiosis. Persistent symptoms and clinical signs reflect multiorgan involvement with episodes of active disease and periods of remission, not sparing the coveted central nervous system.
The capability of microorganisms to cause and exacerbate various neuropsychiatric pathology is also seen in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a recently described disorder attributed to bacteriumStreptococcus pyogenes of group A beta-hemolytic streptococcus in which neurologic tics and obsessive-compulsive disorders are sequelae of the infection. In the current overview, LD and PANDAS are juxtaposed through a review of their respective infectious etiologies, clinical presentations, mechanisms of disease development, courses of illness, and treatment options. Future directions related to immunoneuropsychiatry are also discussed.
Full article here