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Why would myco-p IgG go up?


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Am I ever going to get this all straight????

 

DD10 tested in February 2010

Myco-p

IGG- 1.61

IGM- 667

 

Biaxin from Feb until May 25 when had IVIG

 

Re-test July 2010

Myco-P

IGG- 3.02

IGM- 764

 

ASO down from 448 to 277

DNAse B down from >1360 to 340

 

 

So... what's up with the myco-p elevation? I thought IGG reached its peak on first infection?

 

Peg... someone...help?

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I'm in the same boat as you except her IgM continues to stay high. We are testing again in Aug. My daughters Dr. only orders the IgM and does not seemed concerned about IgG. Her IgM has remained around 3000 for 8 months now.

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Am I ever going to get this all straight????

 

DD10 tested in February 2010

Myco-p

IGG- 1.61

IGM- 667

 

Biaxin from Feb until May 25 when had IVIG

 

Re-test July 2010

Myco-P

IGG- 3.02

IGM- 764

 

ASO down from 448 to 277

DNAse B down from >1360 to 340

 

 

So... what's up with the myco-p elevation? I thought IGG reached its peak on first infection?

 

Peg... someone...help?

Man, I wish I could help, but I just really don't know. But, I think its the IgM that peaks w/ 1st infection. My impression from reading (more than I can comprehend!) is that IgM is produced 1st w/ new infections, until the IgG becomes plentiful enough to take over,(or IgM turns into IgG?) and then, subsequent exposures to the same microbe should trigger immune memory- which is mainly an IgG response. If I don't have that right, I hope somebody will correct me!

 

So based on my understanding your results do not make sense to me...unless the IVIG does something to immune memory- or does "rebooting" the immune system cause it to go back to the IgM production?

Edited by peglem
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Maybe Buster or Kim or someone will know if it looks like a lab error or some type of consequence of IVIG? Dr. K only ordered 3 tests, so he must know what he's looking for and why, I'm just being impatient.

 

Kind of unnerving, though. And I always thought elevated Myco-p went w/temper, raging issues which dd10 hasn't/doesn't exhibit.

 

Bon Jovi, I need you :P

Edited by JAG10
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Am I ever going to get this all straight????

 

DD10 tested in February 2010

Myco-p

IGG- 1.61

IGM- 667

 

Biaxin from Feb until May 25 when had IVIG

 

Re-test July 2010

Myco-P

IGG- 3.02

IGM- 764

 

ASO down from 448 to 277

DNAse B down from >1360 to 340

 

 

So... what's up with the myco-p elevation? I thought IGG reached its peak on first infection?

 

Peg... someone...help?

Man, I wish I could help, but I just really don't know. But, I think its the IgM that peaks w/ 1st infection. My impression from reading (more than I can comprehend!) is that IgM is produced 1st w/ new infections, until the IgG becomes plentiful enough to take over,(or IgM turns into IgG?) and then, subsequent exposures to the same microbe should trigger immune memory- which is mainly an IgG response. If I don't have that right, I hope somebody will correct me!

 

So based on my understanding your results do not make sense to me...unless the IVIG does something to immune memory- or does "rebooting" the immune system cause it to go back to the IgM production?

 

I PM'd IowaDawn too; her child's went up from 3 something to 6.something?? and no rise in IgG for them??

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What does it mean if myco-p is "running high in the general population" at a given period of time? Does that mean it could increase from IVIG?

Well, I suppose you could end up w/ MycoP IgG titers running higher from IVIG, but would they still be that much higher 2 months later?

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Based on Sandra's experience and what I have learnt in the past 5 years together with Marjaana, our loyal GP and friend, who supports us all the way,

IgM rises at infection and goes down rather quickly, IgG is left high, and in Sandra's case kept on going higher and higher for the past 5 years.

We did notice that it reacted and went down after every treatment that was positively effective in relation to the other visible symptoms. IgG went somewhat down (but stayed within the high range) after Mycoplasma Pneomoniae suitable abx (Azith, clarithromycin), Prednisone bursts, IVIG, but went up there after, esp following respiratory infections. It peaked in last December 2009, after almost 5 years, at ca 200 and then reacted beautifylly to now 7 months of Azithromycin, going first down to the 150 range in MArch 2010 and down to 39 in the end of June 2010.

What we presure is that the rising IgG was due to hidden but active Mycoplasma Pneomoniae bacteria and that this is now under control with teh 500mg/day she is still taking.

We were denied IVIG this year (the treatment got stopped way back in winter 2007 even though her reaction was good, because there was a backslide due to medical bureaucracy and the treating neurologist who wanted a quick and absolute recovery had enough of the lengthy truggle with the condition and thought it would be easier for him to classify her as mental and leave ehr untreated) because no one in FInland really knows what to do with the condition and no specialist is willing to contact those abroad with IVIG or PEX experience because "we just do not do things this way".

It seems that high Mycoplasma Pneomomniae IgG and symptoms do react to antibiotics.Sandra did have actual pneumonia caused by Mycoplasma POneumoniae way back in spring 2005 just before all this started.

 

When Marjaana and I presented specialists witht he IgG data we collected and the info on her reactions they dismised it and some said "IgG rises naturally for years" and so forth. We thought it was not a logical way of thinking and decided ABX was better than just leaving her untreated and suffering and thought that what was good for Sammy's Strep could possibly be good for Sandra Mycoplasma. We are still trying.

 

Hope this information helps some.

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