Phasmid Posted June 11, 2010 Report Share Posted June 11, 2010 I need to know why some children do not have elevated Strep titers? Does anyone know the answer? Does this suggest that their bodies are not mounting an immune response to Strep, and maybe that's why they have the problem they do, in terms of PANDAS? Link to comment Share on other sites More sharing options...
peglem Posted June 11, 2010 Report Share Posted June 11, 2010 Well, either the strep are not producing the exotoxins that those titers are raised against or the body is not mounting an attack against them. Link to comment Share on other sites More sharing options...
AmySLP Posted June 13, 2010 Report Share Posted June 13, 2010 We got the answer to my daughter non-existent titers from Dr. B on Weds. You are right on that these kids with low or negative titers are b/c they are not mounting that immune response to strep. He tested strep types and found that she had non-existent immunity to 9 of those-despite havig 4 pneumoccacal vaccines which alone should have booster her immune response to strep. In adddion she's had 15+ positive rapid or cultured strep positives beginning at age 8 weeks and then 3 months of age. He assumes that I likely have the same low immune response to strep, as she should have had that protection from me, hence avoiding strep at such a young age. He did explain that there are children with the samelow immunity to strep that will never develop PANDAS, but that he feels that there is a genetic component to those kids who do. Very interestingstuff! I feel I now have a reason to explain her low/non-existent titers despite months of postitive strep tests. Hope this helps.... Amy Link to comment Share on other sites More sharing options...
Phasmid Posted June 13, 2010 Author Report Share Posted June 13, 2010 VERY interesting! Thank you!!! Link to comment Share on other sites More sharing options...
JAG10 Posted June 14, 2010 Report Share Posted June 14, 2010 This is a post by Dr. Trifiletti: http://www.latitudes.org/forums/index.php?...;hl=hyperimmune He breaks PANDAS down into subgroups such as hyperimmune, immune deficient, ect. although I don't know if the characteristics hold true; i.e. are there PANDAS children who are dx immune deficient yet did have elevated titers? Or PANDAS children who had the wacky sky-high titers yet also turned out have broader immune deficiency? (I think) My girls are in the hyperimmune group; crazy high titers and not all that sickly besides the antineuronal antibody faucet that won't turn off. Link to comment Share on other sites More sharing options...
Phasmid Posted June 14, 2010 Author Report Share Posted June 14, 2010 Thanks for posting this- very informative (though it makes my head ache!) Link to comment Share on other sites More sharing options...
JAG10 Posted June 14, 2010 Report Share Posted June 14, 2010 (edited) . Edited June 14, 2010 by JAG10 Link to comment Share on other sites More sharing options...
Phasmid Posted June 14, 2010 Author Report Share Posted June 14, 2010 I agree with your final comment. However, to me, there's not much difference between 25% and 35%. All that matters to me is that there is "some percentage" of children who do not show an elevation of Strep titers. This is, indeed, a bone of contention. Link to comment Share on other sites More sharing options...
AmySLP Posted June 14, 2010 Report Share Posted June 14, 2010 (edited) Thanks for posting Dr. T's post- I am printing right now for my binder of info. My daughter is definitely type 2-immunodeficient. She had 4 prevnar vaccines and at least 15+ positive strep rapids or cultures in her 5 1/2 years and has not immune response to 9 of the 14 types that were tested. Her titers have always been nonexistent despite having had postive strep testing more than 8 times in a 6 month period in 2008/2009. We are now working with Dr. B and I feel even better hearing he and Dr. T give the same info. on how to treat kids in this "subclass" of PANDAS. Thanks again for posting this, Amy Edited June 14, 2010 by AmySLP Link to comment Share on other sites More sharing options...
faith Posted June 14, 2010 Report Share Posted June 14, 2010 Thanks for posting Dr. T's post- I am printing right now for my binder of info. My daughter is definitely type 2-immunodeficient. She had 4 prevnar vaccines and at least 15+ positive strep rapids or cultures in her 5 1/2 years and has not immune response to 9 of the 14 types that were tested. Her tiers have always been nonexistent despite having had postive strep testing more than 8 times in a month period in 2008/2009. We are now workign with Dr. B and I feel even better hearing he and Dr. T give the same info. on this. Thanks again for posting this, Amy amy, same info on what? couldyou clarify? thanks Faith Link to comment Share on other sites More sharing options...
AmySLP Posted June 14, 2010 Report Share Posted June 14, 2010 Thanks for posting Dr. T's post- I am printing right now for my binder of info. My daughter is definitely type 2-immunodeficient. She had 4 prevnar vaccines and at least 15+ positive strep rapids or cultures in her 5 1/2 years and has not immune response to 9 of the 14 types that were tested. Her tiers have always been nonexistent despite having had postive strep testing more than 8 times in a month period in 2008/2009. We are now workign with Dr. B and I feel even better hearing he and Dr. T give the same info. on this. Thanks again for posting this, Amy amy, same info on what? couldyou clarify? thanks Faith I edited the post...hope that clarifies things! Link to comment Share on other sites More sharing options...
faith Posted June 14, 2010 Report Share Posted June 14, 2010 amy, are you saying you feel Dr. B. gave you the same info that you are now reading that Dr. T. put out? is that what you mean? Link to comment Share on other sites More sharing options...
AmySLP Posted June 14, 2010 Report Share Posted June 14, 2010 yes, It seems that they are both on the same page in regard to treating PANDAS in children with Underactive Immune System/those who are immunodeficent on pneumococcal serotype testing with no rise in titers. Link to comment Share on other sites More sharing options...
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