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Sudden Unexplained Fevers


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Hi all - I have a friend whose 2.5 yr old is having sudden unexplained high fevers. They are every 2 weeks. I feel like it is likely strep related, but thought I'd post the details and see what you all think. There are no behavorial changes - just the fever (during which he just lies in bed & doesn't eat). My thought is that she needs to check the IgG subclasses & treat the child with a few months of antibiotics (she says he is better after antibiotics & will be fine for a longer time afterwards). If anyone knows any studies that would be helpful too. Here is her email that she said I can post:

 

Yes, I went back and checked and the blood work done in September included the “Quantitative Immuglobins”. I do not have a copy of the results….i started requesting copies in October after another 6 vials were taken at the ID specialist’s appt. And during that round, they also did testing in several categories including IgD/Serum, Hematology Miscellaneous, Immunology, etc…. an entire page of items. It was from this round of blood work they said he was not showing enough “robust” responses to the pneumococcal vaccine. They also said his platelets were slightly elevated, however, he started another fever episode the very next day and they later said his platelets “could have been elevated because a fever was coming on…” We are supposed to go for another CBC w/diff and another test during the next fever episode (within the first day of it).

I know our situations are different, but for what it’s worth here is a quick rundown of what we’ve gone through with Connor. If you have seen/heard of anything (or spoken to anyone with similar situation) like this in your research, I am all ears. Thank you again—SO much.

 

When Connor was 5 months old he had bronchiolitis/walking pneumonia. Since then he has had battled respiratory issues and was treated as asthmatic last year…first on Singulair (which gave him in nightmares, so we stopped) and then with daily breathing treatments for approx. 6 months. He has improved tremendously and now only needs breathing treatments as needed if he has a nasty chest cold/cough.

He is one that’s always been sick….You name it, he’s most likely had it! Roseola, strep, countless ear infections (tubes put in), countless “nonspecific viruses”, pink eye (several times), stomach flu (couple of times), eczema/itchy skin, etc….. He has tested positive for strep 3 times (and they’ve done countless cultures). And he is only 2 and ½ years old. The weirdest strep episode came when he was broken out in hives, all over and itching like crazy. No throat symptoms or fever.

The “fever episodes” really kicked in within the last few months. On average, they occur about every 3 weeks. During each episode, his has a high fever, complains about his throat and has no appetite. During the past year, he’s had blood work done five times. And to reinforce that there is something more going on than “just getting sick a lot and/or daycare”, our daughter (10 months old, in the same daycare) is never sick (with the exception of the swine flu, which we are still in shock over Connor NOT getting). As of now, the front runners for his condition (based on dr.’s thoughts….) are PFAPA or cyclic neutropenia.

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I don't really have much input on this one, but here is a thread that after a few posts, wandered off into unexplained fevers...

 

http://www.latitudes.org/forums/index.php?...c=5742&st=0

 

The only other thing I can contribute is that otherPANDAS kids have had bad reactions on Singulair.

 

What are the breathing treatments? A steroid?

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