T_Mom Posted November 5, 2009 Report Share Posted November 5, 2009 Help-- Do you think this is a problem? My younger d (9) is on Augmentin. 500 mg twice a day. We are giving her the Augmentin tablets which say "500/125" From the Wikipedia description below, it appears there can be too much clavulanic acid given. * Note, Sammy was on Augmentin XR which has a lower ratio of clavulanic acid to Amoxicillan (as noted below.) So, if we are using Augmentin, it appears that we should request the form that provides the lowest amount of clavulanic acid?-- especially for younger children? Thoughts? The following quote is from http://en.wikipedia.org/wiki/Co-amoxiclav "Co-amoxiclav was invented around 1977/78 by British scientists working at Beecham, which filed for US patent protection for the drug combination in 1979. U.S. Patent 4,441,609 was granted in 1984.  Dosage The proportions of the two constituents are expressed as x/y where x and y are the strengths in milligrams of amoxicillin and clavulanic acid respectively. However, the branded products indicate their strengths as the quantity of amoxicillin, hence co-amoxiclav 250/125 ≡ Augmentin 250 and contains 250 mg of amoxicillin with 125 mg of clavulanic acid. Standard adult dosages for respiratory tract, urinary, abdominal, and dental infections as well as cellulitis and animal bites is co-amoxiclav 250/125 (one tablet Augmentin 250) taken every 8 hours, which may be doubled in severe infections (as a single tablet of co-amoxiclav 500/125 ≡ Augmentin 500, but not as two co-amoxiclav 250/125 tablets which would double the maximum recommended dose of clavulanic acid). In the US, Augmentin XR (co-amoxiclav 1000/62.5) is marketed for use in community acquired pneumonia with two tablets taken twice a day (giving 4000 mg total daily dose of amoxicillin). Dosages for children are also given three times a day using suspensions containing co-amoxiclav 250/62 in each 5 mL (Augmentin '250/62 SF') for those between the ages of 6–12 years and co-amoxiclav 125/31 (Augmentin '125/31 SF') for those between the ages of 1–6 years. A more concentrated solution, co-amoxiclav 400/57 (Augmentin '400/57 SF'), may be administered more conveniently just twice daily to children from as young as 2 months of age; quantities are based on body weight with 2.5 mL from the age of 2 years and 5 mL after the age of 6 years." Link to comment Share on other sites More sharing options...
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