Predinsone before IVIG?

[Buster]

Please take this poll if your child had IVIG (with or without a dose of prednisone)...

 

Buster

[bmom]

My son did not and has not taken steroids. I was somewhat worried about them as his main symptoms were tics. I also thought I would have him go through with the IVIG no matter the result so I never requested them.

[kim]

looked interesting

 

http://www.jimmunol.org/cgi/reprint/179/8/5571

 

Intravenous Immunoglobulin Therapy Affects T Regulatory

Cells by Increasing Their Suppressive Function

 

excerpt

 

In this regard, glucocorticoids were reported to affect the activity

of Treg cells on the basis of FoxP3 and cytokine expression

(27). FoxP3 mRNA expression was significantly increased in asthmatic

patients receiving inhaled glucocorticoid treatment, systemic

glucocorticoid treatment, or both. The frequency of CD25 memory

CD4 T cells and transient FoxP3 mRNA expression by

CD4 T cells significantly increased after systemic glucocorticoid

treatment. In addition, glucocorticoids induced IL-10 and FoxP3

expression in short-term and long-term cultures in vitro. This study

showed that treatment with glucocorticoids may promote or initiate

differentiation toward Treg cells by FoxP3-dependent mechanism.

Thus, targeting these cells that aim to increase the expression

of these molecules and their suppressive activity could become one

of the tools by which self-tolerance is restored.

Here, and in agreement with all the above, we show for the first

time that IVIg was proven by a unique mechanism to enhance the

suppressive activity of CD4CD25 Treg cells. In this study we

demonstrate that the addition of IVIg to CD4 cells increased

intracellular expression of IL-10, TGF- and FoxP3 when we

gated on CD4CD25high T cells, suggesting that IVIg have the

properties of directly affecting Treg cells. We then established that

the addition of IVIg to the culture of cells increased the suppressive

function of Treg cells by further attenuating TNF secretion by

CD4 effector cells when IVIg was added to CD25 cells.

The mechanisms by which IVIg could possibly affect the function

of Treg cells is still not clear enough. Increased expression of

intracellular IL-10 in Treg cells could inhibit the production of

proinflammatory cytokines by Th1 such as TNF-. In this regard,

IVIg treatment resulted in the down-regulation of the Th1-type

cytokine TNF-, and the up-regulation of the Th2-type cytokine

IL-10 (28). As supported by several experimental studies, IVIg

regulate crucial steps of T cell-mediated immune responses. These

effects involve the modulation of activation, proliferation, differentiation,

apoptosis, and effector mechanisms of T cells. The pattern

of IVIg-T cell interactions is complex, as IVIg may directly

[kim]

came back to edit out a double post and realized that this was a "poll" thread. Sorry Buster. I was going to remove above post, but then thought by kicking it to the top maybe it would catch someone else's attention.

[jan251]

This is a very, very old poll. Any newcomers want to add your IVIg experience to the poll? I'd like to see more anecdotes of success (or not) with IVIg.

 

Here is the old vote:

 

How successful was your IVIG? (check all that apply)

1. Never had IVIG (2 votes [16.67%])

2. at 1 year 90-100% recovered (0 votes [0.00%])

3. at 1 year 70-90% recovered (1 votes [8.33%])

4. back to exacerbations at 1 year (0 votes [0.00%])

5. at 3 months 90-100% recovered (2 votes [16.67%])

6. at 3 months 70-90% recovered (1 votes [8.33%])

7. back to exacerbatons at 3 months (2 votes [16.67%])

8. at 1 month 90-100% recovered (2 votes [16.67%])

9. at 1 month 70-90% recovered (2 votes [16.67%])

10. back to exacerbations at 1 month (0 votes [0.00%])