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This explains why Amoxicillin and penicillin have high failure rates


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http://www.entrepreneur.com/tradejournals/.../169459644.html

 

This article has a good explanation as to why some children's strep is not erradicated by amoxicillin or penicillin. If the person's throat is colonized already with M. catarrhalis OR H. influenza (which are common pathogens in children) those people have a 10-fold increased likelihood of contracting strep. This would be a good article to explain to any physician who is not yet aware of this why they should be prescribing a cephalosporin or macrolide. SO many physicians refuse to accept this and continue prescribing the wrong antibiotics. Perhaps PANDAS children carry more of these 2 pathogens and that is WHY they get strep more easily AND it is not erradicated by Amox/Pen. With that said, I know that Amox/pen DO WORK in SOME people, but the majority of physicians INSIST they work in ALL cases of strep, and that is ABSOLUTELY false.

 

"With coaggregation, the GAS bacteria acquire the ability to attach themselves to the M. catarrhalis or H. influenzae that already colonize the throat at various times during childhood and adulthood (H. influenzae is about 5-6 times more common than M. catarrhalis). While these two organisms have long been known to become pathogenic in certain settings, we are now realizing that they also may serve to enhance the attachment of GAS to throat cells.

 

Indeed, coaggregation is a likely explanation for why some children--such as those more frequently colonized with M. catarrhalis or H. influenzae--are more vulnerable to strep throat than others. Moreover, it also explains our finding that an individual who is colonized with one of those two organisms and then is exposed to streptococcus has a 10-fold increased likelihood of developing strep throat. "

 

Colleen

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