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Mag B6


kim

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I wonder how many were in this study?

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1908782...Pubmed_RVDocSum

 

An open study evaluating the efficacy and security of magnesium and vitamin B(6) as a treatment of Tourette syndrome in children][Article in Spanish]

 

 

García-López R, Romero-González J, Perea-Milla E, Ruiz-García C, Rivas-Ruiz F, de Las Mulas Béjar M.

Departamento de Anestesia y Reanimación. Hospital Costa del Sol. Marbella. Málaga. España. drgarcia.anest@telefonica.net

 

BACKGROUND AND OBJECTIVE: We intended to ascertain the effectiveness and safety of oral solutions of magnesium and vitamin B(6) in alleviating the symptoms emerged during clinical exacerbations in children aged 7-14 years suffering from Tourette syndrome (TS). We also aimed to determine the mean and the standard deviation of such an improvement in order to estimate sample sizes in future assays with a control group. PATIENTS AND METHOD: The treatment under investigation was administered to children diagnosed with TS, in accordance with Diagnostic and Statistical Manual of Mental Disorders, fourth edition -IV, under conditions of clinical exacerbation. The effects were scored on the Yale Global Tics Severity Scale (YGTSS) at 0, 15, 30, 60 and 90 days. RESULTS: The total tics score decreased from 26.7 (t0) to 12.9 (t4) and the total effect on the YGTSS was a reduction from 58.1 to 18.8. Both results were statistically significant. With respect to the application of conventional treatment or otherwise, no significant differences were observed. No side effects were seen. CONCLUSIONS: The treatment assayed is safe and effective in reducing the harmful effects of TS in children. Further studies are needed, with a control group, and evaluation of different doses of the drugs.

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Thank you Kim,

 

This goes along with what my son's Dr said to me in January. He said the best thing for TS is the mag together with vitamin b. I know this study says B6, but it's close enough for me. My son has not had any major tic increases since being on both.

 

I'm so glad studies are being done into this sort of treatment.

 

Lyn.

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Your very welcome!

 

Cheri has worked so tirelessly to advocate for more natural treatments for TS and related disorders, it made me twice as happy to be able to share that!

 

Lyn, glad you found a Dr. that is open to something other than drugs. A neuro that we saw a few years back asked me if I thought that "they" were trying to cover up a cure for TS using vitamins. I wish I would have shot back that no i didn't think "they" were trying to cover it up, because "they" weren't looking.

 

Here are some other studies that you might be interested in reading thru

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1882594...ogdbfrom=pubmed

 

[Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet][Article in Russian]

 

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1876739...ogdbfrom=pubmed

 

Spasov AA, Iezhitsa IN, Kravchenko MS, Kharitonova MV.

Magnesium (Mg) has been proposed to take part in biochemical dysregulation contributing to psychiatric disorders.

 

[The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment]

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1881943...ogdbfrom=pubmed

 

[Effect of some organic and inorganic magnesium salts on lipoprotein state in rats fed with magnesium-deficient diet]

 

Spasov AA, Iezgitsa IN, Kharitonova MV, Kravchenko MS.

 

Low serum magnesium (Mg) concentrations have been reported in patients with atherosclerosis.

 

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1839928...ogdbfrom=pubmed

 

Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency.Spasov AA, Iezhitsa IN, Kharitonova MV, Kravchenko MS.

Institute of Pharmacology, Department of Pharmacology, Volgograd State Medical University. farm@vlpost.ru

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1806216...ogdbfrom=pubmed

 

Vitamin B6 related epilepsy during childhood.Wang HS, Kuo MF.

Division of Pediatric Neurology, Chang Gung Children's Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan. wanghs444@cgmh.org.tw

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1575314...ogdbfrom=pubmed

 

Tocotrienol: the natural vitamin E to defend the nervous system?Sen CK, Khanna S, Roy S.

Davis Heart & Lung Research Institute, 473 West 12th Avenue, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. sen-1@medctr.osu.edu

 

Vitamin E is essential for normal neurological function. It is the major lipid-soluble, chain-breaking antioxidant in the body, protecting the integrity of membranes by inhibiting lipid peroxidation.

 

 

http://www.ncbi.nlm.nih.gov/pubmed/1806216...ogdbfrom=pubmed

 

 

1: Chang Gung Med J. 2007 Sep-Oct;30(5):396-401.Links

Vitamin B6 related epilepsy during childhood.Wang HS, Kuo MF.

Division of Pediatric Neurology, Chang Gung Children's Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan. wanghs444@cgmh.org.tw

 

In some patients without vitamin B6 deficiency, epilepsy can not be controlled without an extra supplement of vitamin B6. The therapeutic role of pyridoxal phosphate (PLP), the active form of vitamin B6, may not be replaced with other forms of vitamin B6 sometimes.

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For anyone who has had success with this combination, could you give me an idea of how much to give? My son is having the same onset of tics that seems to come on every spring. He is 8 and about 52 lbs. We are still on the organic all- natural diet with enzymes, but that's about it. How much b6 do I need to give? 25mg. or do I need to give 50 to see a difference? Thanks!

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Hi Tom's Mom! I'd start with 25 mg and see how he does and then increase to 50 mg if you don't see a difference. We did 25 mg and that was enough for my son. Didn't completely stop his tics but I also wasn't giving him magnesium either.

We're at a point where he has been without tics for a while and it's b/c I took him OFF the B6. He started increasing his tics from November through January so I tried taking the B6 out of his supplements and sure enough, the tics started decreasing and then ended up pretty much as nothing. I see a 'movement' every now and then that I might 'think' is a tic, but don't we all have twitches and facial movements we make at times so if I don't see it more than twice a day I try not to focus on it. I have also taken him off of the glycine b/c his naturopath said it seems like ds is stabilizing for now so he wants to see how we do with minimal supplementation. If things pick up again, we'll start adding stuff back in.

 

Bonnie

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my son definitely does better on P-5-P form of B6

 

also I really do think there is more than just B6 needed to supplement the Bs for TSers...not sure why these researchers only used B6. we have personally seen great benefit from specifically B5 and B1 as well

 

I know B6 facilitates much so maybe that is why they singled it out

 

the magnesium is still #1 on our list of tic reducers

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Chemar,

 

You said you think there's more than just the B6 needed... see, my son is on a B complex and I had been wondering if I should change him to a B6, but I don't think I will now. So far this is working fine for him.

 

I don't like to mess around when something seems to be working.

 

I agree also that the magnesium is a big one. After we missed that week at Xmas we had never seen tics so high in him. I will NEVER miss the magnesium again.

 

Lyn

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Hi,

my son as well is on super b complex but after reading the above posts--I am confused shoud I just be giving B6? Thanks all.

 

Deanna

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Hi deanna

where B6 is very important, yet other B vitamins are as well

 

my son does take a separate B6 in the form of P-5-P but he also gets the full spectrum of Bs from his multivitamin shake and also takes extra methylB12 and Inositol

 

as mentioned in another thread, some people do not seem to tolerate those B complex supps and tend to do better when the Bs are blended in a multivitamin or given individually. my son reacts very negatively to every B complex we have tried

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Looks like the above referenced study is going randomized placebo-controlled double-blind

 

http://www.trialsjournal.com/content/10/1/16

 

Two things that stood out in this were the fact that they were not giving calcium at the same time as magnesium (this is something that I have questioned the wisdom of doing for a while now). It mentions "no dairy." I have read that a little calcium is ok to take with mag for absorbtion, but they should be supplemented well away from each other for the most part (my impression on a topic that there doesn't seem to be a lot of good info on), The other thing was something about TS being more severe when inherited from both parents? Since nooone knows what the "TS" genes are yet, are they just refering to observations in children where both parents have obvious tics?

 

Full PDF

 

http://www.trialsjournal.com/content/pdf/1745-6215-10-16.pdf

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