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Genetic Associations for PANDAS and PANS


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Edited: A final phase of analysis of 23andMe and AncestryDNA data contributed by parents of kids with PANS or PANDAS initially found 5 SNPs statistically significant in these disorders, but only 2 replicated in additional work recently completed (and uploaded as a revision to the report):
SNP _______ risk _ Odds Ratio
rs10493812 __ A ___ 4.1
rs5029936 ___ A ___ 2.0

You can read and download the brief report at https://osf.io/53yve/. If you want to look up these SNPs, it would be good for you to read the 3 short paragraphs of Section 2 of the report.

The spreadsheet with more details at https://osf.io/br2kh/ was not updated for the replication work; it lists the original 5 SNPs (that spreadsheet is best viewed in excel after downloading).
Edited by bobh
Important revision to the report that is linked.
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  • 3 months later...
I just finished another study, checking whether the risk alleles of SNPS for elevated uric acid occur more commonly in PANDAS and PANS.
It looks like the answer is no. The report I did is here: https://osf.io/35sx6/
This idea to check out uric acid genetics came from a P/P mom. I think it was a great idea, that is why I spent a lot of time getting that "no" answer. If anyone else has any good ideas, let me know! I am motivated to make use of this data.
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The post of this thread was edited for an important revision.
Also, my co-author Sam Keating and I recently completed another genetic study about P/P, that is unusual in that it is quite different than a typical genetic association study. The work is done, and with exciting results, but it is not yet formally or informally published - we need some more time for some additional checking. So we can't show results, but you can read what the study is about via its registration plan, here: https://osf.io/ck5un .
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