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Do the effects of ibuprofen ever wear off? **********VERY URGENT********************


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IBUProfen is sort of like a sponge to certain inflammatory agents of the body. There is a group of enzymes called Cytochrome P450 which IBUProfen tries to deplete. P450 is sort of like the ninja squad of the immune system. So, IBU soaks up these inflammatory agents and that keeps the inflammation down.

Of course, the body tries to maintain a level of these agents, especially when needed.

There is no data that I know of that says that IBU stops working over time. Perhaps the body tries to adapt and create more, but I haven't read anything about them. As far as short term, IBUProfen only lasts about 4-8 hours. When I would have bad flare ups, I would take about 800mg (4 tabs) once, and then be good for a while. My daughter is on 200mg 3 times a day. It seems to affect her moods for the better.

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