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Fever and chills AFTER starting abx?

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We'e new at this... 6 yo DS just started Amoxicillin (250mg 2x) yesterday and just before giving him his 3rd dose. He just spiked a fever 102.6F and has chills. Seems crazy since for the last couple weeks he's only had low grade temps. Could this be a J-H reaction?



Dx "suggestive of PANS"

Strep B infection and scarlettina type rash at onset

Sib w active strep A same time

History of tick exposure but neg test resuts




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