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Specific Antibody Deficiency progress to CVID?

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DS17 has IGG, IGA and IGM that are lower each time we test. He responded to 6/23 serotypes after Pneumovax.

He has specific antibody deficiency and selective IGM deficiency.


IGG went from 1011 to 830 (694-1618)

IGA from 140 to 90 (81-463)

IGM from 40 to 18 (48-271)


subclass 3 is low (23)


I understand from immunologist that specific antibody deficiency can progress to CVID.


Does anyone have experience with this? I thought I understood these levels should be rising into adulthood not dropping?

Edited by Sonshine

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