Tissue Transglutaminase IgA

[ibcdbwc]

Hi Everyone,

 

Anyone know anything else about tissue transglutaminase IgA? DS13 tested high out of the reference range. It's a marker for Celiac and so we are now gluten free.

 

Traditional medicine suggests confirming a diagnosis of Celiac via biopsy which we will not do - especially since we were going gluten free anyway.

 

But the uncertainty still has me wondering. Some reports suggest other autoimmune conditions can raise ttgA. I am wondering if I should pursue even MORE testing or just assume Celiac.

 

Or could chronic NSAID and antibiotic use inflate the marker?

[ibcdbwc]

I should mention, we know we have some other autoimmune issues in play already. Anti-adrenal antibodies were detected and transient thyroiditis. His hgbA1c is normal but always on the high end of normal. He's never been tested for arthritis despite intermittent (with flares) complaints of joint pain. He was given a diagnosis of autoimmune encephalopathy and has low IgG and subclass IgG3. We will pursue IVIG in June.

[PowPow]

Just curious, will this be the first ivig for your child?

[ibcdbwc]

Hi Pow Pow,

 

Yes, this will be his first IVIG. We were able to manage via antibiotics for several years. However, since September he has tanked and is flaring more often and more dramatically.

[Rachel]

My son had this test. He was negative. So if we go gluten free, it will be just to give his immune system a boost.

[sf_mom]

You need to to check for mold via the Real Time Labs Mycotoxin Urine Test...... It can raise the transglutaminase IgA antibodies and the individual appears to be Celiac's. This was true for our older son. We are not currently Gluten Free because we were chasing food allergies possibly from the mold related issues. Now, we are just treating for mold.

 

Here is a little blurb on the topic.

 

Quite interestingly, the genes for celiac disease/gluten intolerance have a significant overlap with the mold genotypes (e.g., DQ2 accounts for 90% of individuals diagnosed with traditional celiac disease). Thus, many individuals with a mold illness may be initially diagnosed only as having gluten intolerance, yet they never fully recover on a gluten-free diet alone. Coincidentally, the low amylose diet recommended as part of the treatment protocol is naturally a gluten-free diet. For further information on celiac disease/gluten intolerance and available testing, go here. -

 

See more at: http://www.betterhealthguy.com/topics/mold#sthash.eWSqcZAZ.dpuf

Edited April 1, 2014 by sf_mom

[ibcdbwc]

Wow sf_mom that could be something. We do have a confirmed problem with aspergillus in the house!

[sf_mom]

I should add it was also true for DD. We have not tested younger DS yet but are treating him for mold.

 

Our children are not fully biologically related and all have similar immune deficiencies inclusive of IgA. DD and older DS have transglutaminase IgA antibodies. I tend to believe some of this stuff is more environmental.

 

The test is expensive at over $600 'I think' but it will be a life saver with regards to your PANS treatment if it is mold. Mold can create huge hurdles with recovery if not diagnosed. Thankfully our children moved slowly toward recovery even with mold issue..... However, I have greatly improved since moving and older DS's cough is almost non existent. We think the mold was definitely in his lungs as well as liver. Recently he has had slightly elevated liver enzymes.