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Buster

What questions are various research papers answering...?

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Hi folks,

 

I've been going through the various papers and trying to tease out what questions the researchers are actually answering. If you've been reading papers you think are signfiicant can you add to this list or send me a message regarding other questions/papers? I'm not looking for "review" articles, but rather people running experiments that are testing certain hypothesies.

 

 

Whether sudden onset OCD is correlated with untreated strep infections?

 

[swedo1997] S Swedo et al, "Identification of Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections by a Marker Associated With Rheumatic Fever", Am J Psychiatry 154:1, January 1997 http://ajp.psychiatryonline.org/cgi/reprint/154/1/110.pdf

[swedo1998] Swedo SE et al., "Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections: Clinical Description of the First 50 Cases", Am J Psychiatry 155:2, February 1998. http://ajp.psychiatryonline.org/cgi/reprint/155/2/264

Whether established OCD and/or tic disorders have exacerbations associated with treated strep infections?

 

[Kurlan 2008] Kurlan R, et al. Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study. Pediatrics. 2008 Jun;121(6):1188-97.

[Leckman 2011] Leckman JF, et al. Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study. J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):108-118

Whether symptoms remit when treated with antibiotics?

 

[Garvey 1999] Garvey, MA et al. A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. Biol Psychiatry. 1999 Jun 15;45(12):1564-71.

 

 

[snider 2005]. Snider2005, et al, Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry. 2005 Apr 1;57(7):788-92.

[Murphy2004] Murphy TK, Muhammad S, Soto O, et al. "Detecting pediatric autoimmune neuropsychiatric disorders associated with streptococcus in children with obsessive-compulsive disorder and tics", Biological Psychiatry, Volume 55, Issue 1, Pages 61-68, January 2004 http://www.journals.elsevierhealth.com/per...0704-2/abstract

Whether symptoms remit when treated with IVIG/PEX?

 

[Perlmutter1999]Perlmutter SJ, Leitman SF, Garvey MA, "Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood", Lancet 1999; 354 : 1153 58 http://intramural.nimh.nih.gov/pdn/pubs/pub-5.pdf

Whether strep colonization alone is sufficient to trigger exacerbations?

 

[Dileepan 2011] Dileepan T, et al. Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection. PLoS Pathog. 2011 Sep;7(9)

[Wang 2010] Wang B, et al. Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5937-42.

[ Hyland 2009] Hyland KA , et al. The early interferon response of nasal-associated lymphoid tissue to Streptococcus pyogenes infection. FEMS Immunol Med Microbiol. 2009 Apr;55(3):422-31.

[Constalonga 2009] Costalonga M, et al. Intranasal bacteria induce Th1 but not Treg or Th2. Mucosal Immunol. 2009 Jan;2(1):85-95.

 

Whether anti-neuronal antibodies are diagnostic for PANDAS?

 

[singer 2008] Singer, et al. “Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.”, Pediatrics. 2008 Jun;121(6):1198-205.

 

[Kirvan2003] Kirvan CA, Swedo SE, Heuser JS, Cunningham MW, "Mimicry and Auto-antibody mediated neuronal Signaling Cells in Sydenham Chorea", Nature Medicine 9, 914 - 920 (2003) http://www.pandasnetwork.org/Cunningham.NMpaper[1].pdf

[Kirvan2006] Kirvan CA, Swedo SE, Kurahara D, Cunningham MW, "Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea". 2006 Autoimmunity 39 (1): 219. http://www.pandasnetwork.org/CunninghamJNICaMKinase.pdf

[Dale 2012] Dale RC, et al. Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders. Brain. 2012 Nov;135 (Pt 11):3453-68. doi: 10.1093/brain/aws256. Epub 2012 Oct 11.

[brilot 2011] Brilot F, et al. Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome. Neurology. 2011 Apr 26;76(17):1508-13.

 

Whether antibodies to GABHS trigger behavioral changes (in mice)?

[Yaddenapudi 2010] Yaddanapudi K, et al. Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Mol Psychiatry. 2010 Jul;15(7):712-26.

[Hoffman 2004] Hoffman KL et al, A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection. J Neurosci. 2004 Feb 18;24(7):1780-91.

 

Whether exacerbations are correlated with otherwise asymptomatic carriage?

??? Kurlan?

 

 

Any others?

 

Buster

 

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Whether established OCD and/or tic disorders have exacerbations associated with treated strep infections in kids with Tourettes (not true PANDAS)?

 

[Kurlan 2008] Kurlan R, et al. Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study. Pediatrics. 2008 Jun;121(6):1188-97.

[Leckman 2011] Leckman JF, et al. Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study. J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):108-118

note: both of the above studies (2008 Kurlan, 2011 Leckman) used the same group of Tourettes kids. This is also the same group of kids as in my next comment (Singer 2008).

Edited by EAMom

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Whether anti-neuronal antibodies are diagnostic for PANDAS?

 

[singer 2008] Singer, et al. “Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.”, Pediatrics. 2008 Jun;121(6):1198-205. NOTE we find out later the kids in this group were not true PANDAS, but garden variety Tourettes.

Thank you Neil Sweidy http://www.bostonglobe.com/magazine/2012/10/27/the-pandas-puzzle-can-common-infection-cause-ocd-kids/z87df6Vympu7bvPtapETLJ/story.html

"Most of the kids in the study resembled those he regularly sees in his clinic — children with “garden-variety” Tourette’s and OCD. But after working with more physicians treating PANDAS patients, he had come to see firsthand that there was a distinct group of kids who literally had changed overnight, with dramatic onslaughts of OCD and other symptoms. And these “true” PANDAS/PANS cases weren’t represented in his study in any meaningful way."

Edited by EAMom

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Your PM box was unable to accept more messages so I will post this here:


I am currently a volunteer data collector for a study that states "the purpose of the study is to understand the meaning of the PANDAS experience through a study of the language and metaphors used to describe the lived experience". Should you require further information you may contact me at mmcrombez@gmail.com

Mary Crombez

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Whether symptoms remit when treated with IVIG/PEX?

 

[Perlmutter1999]Perlmutter SJ, Leitman SF, Garvey MA, "Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood", Lancet 1999; 354 : 1153 58 http://intramural.ni.../pubs/pub-5.pdf

 

 

might add the Turkish adult men with pandas paper to this...

http://www.google.com/url?sa=t&rct=j&q=therapeutic%20response%20to%20plasmapheresis%20in%20four%20cases%20with%20obsessive-compulsive%20disorder%20and%20tic&source=web&cd=3&cad=rja&ved=0CDcQFjAC&url=http%3A%2F%2Fwww.turkpsikiyatri.com%2FC18S3%2Fen%2FtherapeuticResponse.pdf&ei=gESmUaL8AePliAKI_IG4Ag&usg=AFQjCNEL0Lh7G3gqDgrDPO_ynhTnTHCkFA&bvm=bv.47244034,d.cGE

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I think you should also put a little note next to each paper as to what the result was...eg yes, no, or inconclusive due to low incidence of strep infections. etc

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thanks to both of you for keeping us all up to date!

 

I'm waiting for Drittan Agalliu's reseearch on repeated strep infections and effect on the BBB to come out From his site - "Agalliu D*, Nimmerjahn A*, Arac A, Perrino J, Schnitzer M and Barres BA. Development of reporter mice to image dynamic structural and functional changes in the mammalian blood-brain barrier in health and disease. (Manuscript in preparation)." His site read "in peperation" for months.

 

Wasn't there a doc doing PET scans on pandas kids ? Chugani (or somehting like that). I thought he was doing a study.

 

Cunningham is suppossed to have several papers "soon"..maybe you should leave a "manuscript in process note" in those sections.

 

Below is a review paper and you aren't looking for those- but I like the way it summarizes research in the area - and if you decided to put together something like EAMoms suggestion on the outcomes for each paper - there is a chart in there that might be a good model. Paper itself is good and talks alot about PANDAS (and I like that the researcher in the world of autoimmune world and taking a fair look at pandas and including it in their papers. Paper called Autoimmune Basal Ganglia Disorders

http://jcn.sagepub.com/content/27/11/1470.full.pdf+html

 

I wish there were more....

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Don't count on Dr Chugani. If your child fits *his* criteria, you'll get the PET scan and treatment. If not, you are out of luck. No idea when he might publish. He's been doing the PET scan with a special tracer he formulated for several years now.

 

By his criteria, I mean his criteria of PANDAS. His PET scan has been negative for a number of kids known to have PANDAS.

Edited by nicklemama

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