Autism and Methylation

[LNN]

This isn't a new article (2007) but it outlines one theory of what's going on in autism. I personally think, after 5 yrs of battling these issues, that this is also a little of what happens to Pandas kids. They may be able to maintain a level of "normal" when healthy, but when extra resources are needed in the system to fight infection, when the body self-attacks, you see an imbalance of neurotransmitters, a dysfunction in the body's ability to detox. Too much oxidative stress breaks the camel's back.

 

Addressing methylation hasn't "cured" the Pandas - DS is still vulnerable to infection triggers. But addressing his unique methylation roadblocks has helped in many ways.

 

http://www.utdallas.edu/~mxa049000/lessons/research/literature/Autism/new/deth%20autism%20methyl%20hypoth%2009.pdf

1. Sulfur metabolism and oxidative stress. .

2. D4 dopamine receptor-mediated PLM

3. Heavy metals, xenobiotics, redox and methylation. .

4. Oxidative stress in autism

5. Redox/methylation-related genetic factors in autism.

6. A redox/methylation hypothesis of autism . . .

The authors are from Northeastern in Boston. Anyone ever work with any of them?