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DD had shots for 18 mos w/o incident. She's C677T hetero. I don't think shots effect this part of the methylation cycle.

FWIW, The shots helped a lot but we stopped shots b/c she developed needle phobia that got worse as time went on, not better. Unfortunately, allergies got worse again. So we just started sublingual drops. I thought these were only available for food allergies but no. These are for environmentals (weeds, grasses, mold, plus cat). One drop under the tongue 3x/day. Just started 3 days ago. Biggest challenge will be remembering to give 3x/day...

 

But now that you have me thinking about it, I'll go ask on MTHFR Support just to see what they have to say...

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