eljomom Posted January 7, 2012 Report Share Posted January 7, 2012 Just happened to google Cephalexin and anti inflammatory and the first link was this one. NOT related to pandas, but interesting list of antibiotics and why they might be working..... was considering taking her off, but now....??? My link Link to comment Share on other sites More sharing options...
PowPow Posted January 7, 2012 Report Share Posted January 7, 2012 cool, cool, cool eljomom! thanks for posting this!! Link to comment Share on other sites More sharing options...
EAMom Posted January 7, 2012 Report Share Posted January 7, 2012 Just happened to google Cephalexin and anti inflammatory and the first link was this one. NOT related to pandas, but interesting list of antibiotics and why they might be working..... was considering taking her off, but now....??? My link very cool! Link to comment Share on other sites More sharing options...
MomWithOCDSon Posted January 7, 2012 Report Share Posted January 7, 2012 Good find! Here's another full paper on the topic: Immunomodulatory Properties of Antibiotics Yes, items such as these can make you think twice about taking your kids off. There's also evidence that certain classes of antibiotics can be glutamate modulating, which can also be helpful in kids with OCD and/or ASD behaviors associated with their PANDAS. But that's another topic altogether. Assuming you have access to antibiotics without a problem, they're not doing damage to your kids' gut, and you don't have an idealogical issue with using them for purposes beyond treating active infection or warding off potential oncoming infection, I suppose your best guide to when to keep your child on, and when to take your child off, might be the impact you see in terms of behaviors off and/or on? With our DS, for the first couple of years, it would be a matter of 8 or 10 days off of the abx, and we'd start to see fairly dramatic regression in terms of behavioral gains; the OCD would flare up, his distractability would increase, his emotional lability would increase, etc. Now, finally, after nearly 2 fulls years on abx, we've been able to wean him off without any dramatic behavior repurcussions. Why? Not sure. But that's our reality. In our case, because the behaviors are nearly 100% OCD-related, it may be that the glutamate-modulating properties of the abx were picking up where his own chemistry was failing him. Or perhaps the anti-inflammatory properties were helping keep the BBB closed and protect his basal ganglia from further immune system-related onslaught. The "why" may remain a mystery for another decade or more, so you have to trust your own powers of observation and intuition, IMHO. Good luck! Link to comment Share on other sites More sharing options...
Mayzoo Posted January 8, 2012 Report Share Posted January 8, 2012 (edited) Anyone here every tried roxithromycin (Rulide)? It is not available in the USA, but maybe someone here has tried it that is not in the USA. This is a good paper: Link "Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin" By F. Scaglione and G. Rossoni published in the Journal of Antimicrobial Chemotherapy (1998) 41, Suppl. B, 47-50 Edited January 8, 2012 by Mayzoo Link to comment Share on other sites More sharing options...
Mayzoo Posted January 8, 2012 Report Share Posted January 8, 2012 Here is another good article, but it is long (37 pages). I have not read it all, but what I have read looks interesting. Link "Phagocyte Functions: Immunomodulation Interference of Antibacterial Agents with or ''Immuno-Fairy Tales''?" by Marie-Thérése Labro 10.1128/CMR.13.4.615-650.2000. Clin. Microbiol. Rev. 2000, 13(4):615. DOI: Link to comment Share on other sites More sharing options...
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