Christianmom Posted November 29, 2011 Report Share Posted November 29, 2011 I read this article today and thought it might apply to my son. It is called "Disorders of Tryptophan Metabolism:" http://www.associatedcontent.com/article/2729975/disorders_of_tryptophan_metabolism.html?cat=5 My son's tryptophan was high on his recent amino acids test. He is also has a single C667T MTHFR mutation. Here is the part of the article that interested me: Acute Intermittent Porphyria In this disease there are psychiatric symptoms. It seems that a key enzyme in the metabolism of tryptophan is low in this disease. This causes tryptophan to accumulate in the brain and cause psychiatric symptoms. Tryptophan pyrrolase breaks down tryptophan in the kynurenine pathway, which is the main pathway of tryptophan metabolism. Another pathway leads to serotonin. There is no deficiency of serotonin in this disease. A factor that is low in porphyria is required by this enzyme. Porphyria is treated by heme, which is the factor. I was wondering if anyone has had this test done, which lab ran it, and did it give you meaningful information. Thank you! Link to comment Share on other sites More sharing options...
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