P_Mom Posted January 31, 2011 Report Share Posted January 31, 2011 Pepsi funds have been used to begin experimentation on antibody producing cell lines previously produced in our laboratory from Pediatric Autoimmune Neuropsychiatric Disorder(PANDAS). Our hypothesis is that autoantibodies are produced against the brain after infections and can signal receptors on neuronal cells in the brain to be abnormal and cause neurologic, movement and behavioral disturbances. We wanted to study the immune cells and the anti-autoantibodies which may be the cause of the disease. First, we hired Dr. Jonathan Zuccolo, a B cell immunologist from the University of Calgary. The funds allowed us to be able to hire an expert in antibody producing cells (B cell immunologist). Dr. Zuccolo has begun to grow and investigate 3 groups of human hybridoma B cell lines producing autoantibodies from PANDAS. The cell lines were cultured by tissue culture in Iscove's Modified Dulbecco's medium and the antibodies produced by these cell lines were analyzed for reactivity with brain autoantigens which may be targeted in PANDAS. These experiments test for binding and then also for functional signaling properties of the autoantibodies which may be their mechanism in disease. These studies will use the second half of the PEPSI funding to complete these experiments. We will acknowledge PEPSI in all published works from this study. Link to comment Share on other sites More sharing options...
norcalmom Posted January 31, 2011 Report Share Posted January 31, 2011 thanks for the update...any idea when study results will be available? Link to comment Share on other sites More sharing options...
eljomom Posted January 31, 2011 Report Share Posted January 31, 2011 Would love to also know if this will help in treatment (or is this for diganostics)? Thanks for sharing. Link to comment Share on other sites More sharing options...
P_Mom Posted January 31, 2011 Author Report Share Posted January 31, 2011 Just so everyone knows....I am sharing everything I can. I have no specifics on dates or what the outcome of this research will be. Remember, it is research, so, who knows what will come of it....we can hope for the best. Atleast someone is researching PANDAS and trying to give us answers....hope, etc. All I have to share is what is posted...sorry, but, we are going to have to wait........."the waiting is the hardest part." Link to comment Share on other sites More sharing options...
colleenrn Posted January 31, 2011 Report Share Posted January 31, 2011 Yay!!!!!!!!!!!!!!!!!! Thanks for posting. Let the skeptics dispute these findings. Soon they won't be able to. Colleen Link to comment Share on other sites More sharing options...
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