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Good afternoon everyone, My dd is 2 1/2 years old and has a hx of autism (classic) and recurrent infections (otitis media with ear tube surgery, sinus, rsv, respitory) and is a carrier of a rare immunodeficency called CGD passed on from her father, she doesn't have the disease but is a carrier. She recently had quantitive immunoglobulin tests and antibody titers which revealed normal IgG 575, IgM 125 and IgA 32. Her total immunoglobulins levels were within normal limits but 3 out of 4 igG subclasses were low and 9 out of 14 pneumococcal antibody titers were low, below 1.0. Her doctor said thst this explains her frequent infections and reccomended a pneumovax 23 vaccine to test an antibody response with repeat labs in 4-6 weeks, which she recieved yesterday. The diagnosis code on the lab order was 279.3 (unspecified immunodeficency) Should i be concerned for her being diagnosed with any immunodefiencies and should she have any reactions or regressions since she had pneumovax yesterday? she had 4 prevnar vaccines per immunization schedule since birth, shouldn't those have created an immune response, i hope she doesn't fail titers with the revax. I am also awaiting results of a sleep deprived EEG with her neurologist for frequent staring spells vs. Petit mal/absence seizures and she was recently started on Clonidine 0.1mg 1/4 tablet before bed for sleep disorder and hyperactivity. Should i be concerned? Any suggestions or similar expierences would be apprciated, i am so concerned given her myraid of issues as of late. thanks
