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The results obtained from this study suggest that streptococcal infections can alter gut microbial communities leading to a pro-inflammatory state in the gut by selecting for specific bacterial strains that are normally associated with gut inflammation and activation of the immune response (Figure 7). This condition is likely maintained in patients, even after the infection itself has resolved. Moreover, an altered GM composition could have indirect effects by reducing the production of metabolites involved in important brain functions such as SCFA, D-alanine and tyrosine metabolism, and the dopamine pathway. Thus, the GM composition may possibly influence behavior, as clinically observed in PANS/PANDAS patients. https://www.frontiersin.org/articles/10.3389/fmicb.2018.00675/full
Very interesting reading from AoA Contributing Editor Teresa Conrick: http://www.ageofautism.com/2016/12/cdc-denying-harmful-human-vaccine-consequences.html "A particularly notable finding in our study is the 900% increase in noninvasive pediatric vaccine-related isolates that was associated with serotypes 19A...serotype 19A frequently recovered from middle ear fluid specimens. ● It is noteworthy that serotype 19A—the original multidrug-resistant serotype reported from South Africa in 1978 —emerged in the United States after the introduction of PCV7 in 2000, and many of these isolates are multidrug resistant." "Vaccination with PCV-7 resulted in a shift in bacterial community composition and structure, with an increase in presence or abundance of several anaerobes, such as Veillonella, Prevotella, Fusobacterium, and Leptotrichia species; gram-positive bacteria, such as Actinomyces and Rothia species, and nonpneumococcal streptococci; and gram-negative Neisseria species…. Together with S. pneumoniae nonvaccine serotype replacement, these effects may further jeopardize the net health benefit of vaccinations with PCV.” http://www.ageofautism.com/2014/06/the-human-microbiome-evolution-of-vaccine-exposure.html Vaccination is likely to have important consequences for the NP microbiome. Current pneumococcal vaccines are directed against multiple serotypes thus potentially eliminating these from the microbiome. Based on observations on this and other vaccines, new organisms are expected to move into the empty niches created by vaccine elimination of organisms. Thus the structure of the microbiome is altered by vaccines. The unintended consequences of this alteration remain to be seen. It seems very possible that if the microbiome takes a hit, like mercury exposure or immune manipulation via vaccination, the more we may see the immune system diseases rapidly rise. Autism and PANDAS/PANS and other immune-damaged diseases deserve huge concern and true research." http://www.ageofautism.com/2014/04/autism-does-mercury-modulate-the-microbiome.html#more "... here are studies showing how it is the microbiome, not genes, that will lead the way in helping so many stricken with these symptoms: • That veil is only very recently being lifted with respect to a potential role for autoimmunity in neuropsychiatric disorders. This shift has occurred as evidence accumulates to support the idea that dysregulated cross-talk between the brain and the immune system is an important contributor to the pathogenesis of conditions as diverse as schizophrenia, mood disorders, autism spectrum disorders (ASDs), obsessive-compulsive disorder (OCD), Tourette syndrome and other tic disorders, attention-deficit hyperactivity disorder (ADHD), anorexia nervosa, narcolepsy, posttraumatic stress disorder and myalgic encephalomyelitis/chronic fatigue syndrome (CFS).[4,5] In addition, intriguing new evidence lends support to the possibility that not only the microbes associated with infectious episodes but also the bacteria of the gut microbiome can foster the production of brain-reactive autoantibodies, and that these microbe-induced antibodies provide the critical link between infection and neuropsychiatric disorders. • ….Eventually, as more pathogens are incorporated into the microbiome and levels of dysbiosis increase, people begin to present with symptoms characteristic of an autoimmune or inflammatory diagnosis......There is increasing evidence that autoimmune diseases run in families due to the sharing of common microbes.... The microbiome a child develops is a direct reflection of those harbored by the mother and close relatives. Microbes are introduced by a multitude of sources including the placenta, sperm,egg, breast milk, and vaginal canal. …. Autoimmune diseases are more likely passed in families due to inheritance of the familial microbiome than inheritance of Mendelian genetic abnormalities.” "Note that the above study refers to "regressive-type" autism as a disease. I have watched my own daughter suffer for years -- infections, pain, neuropsychiatric symptoms related to PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and an autoimmune diagnosis shown by antinuclear antibodies. Since 1938, those with the symptoms called “autism” have been put on a spectrum, from low functioning to high functioning. It is very possible that their functioning had everything to do with a dysfunctional microbiome." Here is a good video by Stephanie Seneff on the association between glyphosate, vaccine constituents, gut bacteria and autism: https://www.youtube.com/watch?v=o3P6wVUH0pc
I found a great article this morning that discusses the microbiome and it's connection to brain related disorders such as autism. Great explanations of GcMAF and nagalase as well for anyone who's interested. https://riordanclinic.org/2013/01/the-super-probiotic/
The Chronic Lyme Disease Summit http://chroniclymediseasesummit.com/ is a free online conference starting today. There are many great speakers and topics lined up, and I encourage anyone still looking for answers, even if you've ruled out Lyme or don't think it's a possibility, to check it out. Much of it will be relevant to PANDAS/PANS, whether or not Lyme is involved. Speakers include Dr. Horowitz, Lee Cowden, Scott Forsgren (Better Health Guy), Kenneth Stoller, and Joseph Mercola, just to name a few. Topics include mitochondrial dysfunction, brain conditions, stress and emotional trauma, treating anxiety and panic with tryptophan and GABA, energy medicine, Chinese medicine, trigeminal neuralgia, IV vitamin C, rife, infrared technology, sugar, mold, nutrition and detox, gut microbiome, biofilms, GAPS diet, ketogenic diet, grains = inflammation, cancer, heavy metals and more. They have several speakers each day and you have 24 hours to watch their talks for free.