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Methylation Advice Please
maybaby posted a topic in PANS / PANDAS (Lyme included)Every time I try to discuss methylation with my DD's LLMD, he tells me not to worry about it b/c treating her lyme is the big focus. My gut tells me that I need to consider and address her methylation results, especially as we continue to detox during her lyme treatment. My DD is constantly in an emotionally restless state (we never know when we're going to have a good or bad day). Her tics, rages, and ability to be and feel " calm and present" wax and wane with her medical treatment. Here are my concerns re: her 23 and me results: Detoxification: CPOX4- GT (1/2) CYP1A1- CT (1/2) CYPD2D6- AG (1/2) GSTP1- AA (2/2) NAT2- AG (1/2) Neurotransmitters: COMT V158M & H62H +/+ DAOA- AA (2/2) GAD1- AA (2/2) MAO-A +/- Folate One-Carbon Metabolism/Methylation: CBS C699T +/+ CBS A360A -/- MTHFR C677T +/- BHMT-02 & 08 +/- Endocrine: VDR BSM & TAQ +/- I've done nutrahacker and tried to read (with many failed attempts) the Heartfixer document. I'm most concerned with her homozygous CBS, COMT, DAOA, and GAD1 (high glutamate/low gaba) mutations. I also can't figure out if she is an over/under methylator. I don't know what to make out of her detoxification mutations. When I showed the doctor her 23 and me results, he said to "watch out" for histamine??? I'd love any advice you have to point me in the right direction for how to interpret her results, recommended supplements and a treatment protocol.