I feel for you and I completely understand how you feel. I have 3 pans children. The earth shattering piercing screams is enough to make one go insane. I feel at times I'm living in a mental asylum. I think it's the OCD, when their compulsion isn't met that makes them scream their ear piercing screams with their complete being. I didn't answer right, or drop what in doing to answer them in that split second makes them go off. It's heart wrenching and its unbearable for us having to deal with it. Buy yourselves several sets of ear plugs. I'm surprised I haven't gotten deaf by now. I pray you find answers and find a treatment that helps. I'm sure others will chime in with great suggestions. Have you tested for infections other than strep, mycoplasma, coxsakie, Lyme, Ebv all triggers.