Report Rituxan (rituxamb) treatment in PANS / PANDAS (Lyme included) Posted February 15, 2015 Hi there, I have a DS16 and DD 12. Both were doing great after a long road of treatments. (Augmentin 875 mg twice a day, several steroid courses, IVIG - which helped ds briefly but not dd and finally plasmapheresis 2011 brought the lasting (until Nov 2014) healing. Well...let me quantify that.... After the plasmapheresis we tried sending them back to public school when they started losing ground. We began homeschooling and have been doing GREAT until November when my son was exposed to strep at one of his co-op classes. PANDAS is back with a vengeance...food restrictions (he's always been slim and has lost 15 lbs since Nov) , severe OCD (won't leave room). I could go on with the symptoms but will save you the boredom.... Anyways, Our neurologists recommended A series of 4 Rituxan infusions (also called Rituximab) to eliminate his 'B' cells which are the cells that contain the antibodies that are causing PANDAS. Insurance denied the infusions so we borrowed the money and he finished his last infusion Jan21. My question is if anyone else has tried this treatment. How long until you saw improvements? Thanks!