Hi tpotter, no we haven't felt the need. Our Pediatric LLMD likes to keep the protocol as simple as possible, with as few "extras" as possible. DS10 takes Burbur, parsley, multivitamin, cod liver oil, vitamin c, and a probiotic as well as methylb12 and methyl folate (the latter 2 are to address a single MTHFR 677 mutation). We also opt to throw in the occasional Epsom salt bath for good measure (for detox). So far it seems to be enough and DS continues to recover while on his pulse antibiotic treatment. Our LLMD runs safety labs every 3 weeks to check metabolic/liver function, which is very reassuring as the parent I can tell you!