Report Help! Are there ANY anti-anxiety meds, etc that work for PANDAS ki in PANS / PANDAS (Lyme included) Posted May 18, 2016 I was the OP on this thread so I thought I'd pop back in. I haven't been on the board for a while so I didn't realize this thread had been bumped back up. We never did SSRIs or anti-anxiety meds. In a moment of absolute panic I convinced his dr to prescribe lamictil based on several posts on this board, but I never gave it to him. His therapist at the time didn't think he was a danger to himself so we just held on and tried to get through it. We were seeing a therapist (which he hated) and a adolescent specialist weekly for weight checks. As his nutritional status and weight improved, the body dismorphia and the depression lifted. Based on my own research on anorexia, I started him on zinc supplements, and that is the thing I think made the most difference in the long run with getting him over the anorexia and depression. He just sort of came through it. After doing 23andMe and a billion hours of reading/research I find I still don't understand most of the methylation stuff but we are making some progress. We haven't had a repeat of that awful 6 months at least. He currently takes Azith, lithium orotate, Magnesium, Zinc, hydroxy B12, CoQ10, Iron (he's a vegetarian), and probiotics. I'd like to tweak that list a bit but I'm scared to rock the boat. I did a HTMA on him a while back and there are some issues there, but I haven't had time to really figure it out and determine what else to add in. He also basically refuses to take any more supplements than he is taking now. We also tried Inositol in the past and it didn't help, probably because it's a methyl donor and he can't tolerate methyl donors, even though he needs them desperately (very confusing genetics). That could be why your son doesn't do well on it either. You might give lithium orotate a try, along with B12 and magnesium. If you haven't done MTHFR testing, probably try hydroxy B12 rather than methyl B12. Or try small doses of methyl B12 and watch to see if it makes him flare. None of it is a magic fix, at least for us. It's been slow going and just trying to get incrementally better. This all sounds very familiar. Our DS (14) has been battling with scrupulosity OCD for a few months now. However, in the last six weeks, it has been an all time high since our journey began with PANS back in late 2013. He is pretty much overcome with doubting his faith and doing a number of compulsions to "overcome" the obsessive thinking. It has become pretty much non stop the past few days and is starting to effect his work and ability to focus. We started our journey on azith for high myco p and my son initially responded almost immediately and we saw almost immediate relief and we stayed on for a few months and came off, using only for flares. However, it seemed that it was no longer effective when we picked it up this spring, so we switched to biaxin....did nothing for the 30 days we took it. We have now been off abx the past week or so...but have talked with DR about going minocycline or doxy. He wanted us to try a round of inositol dosing for 6 weeks before looking at going to new abx. Well, the inositol has done nothing over past three weeks and seems to make it worse. At this point, we are just trying to dampen things so that CBT can be effective. We are using NAC, vit c, probiotic, omegas, and multi vit. I don't want to go SSRI unless absolutely necessary and like earlier post I would be interested in something fast acting to take the anxiety down some to we can at least get through therapy sessions. Any suggestions or am I missing something that may need to be addressed?