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thereishope

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  1. Invitation:

    http://pandasnetwork.org/wp-content/uploads/2012/05/UCIAdv_PANDAS_InviteFlyer_F.pdf

     

    UC Irvine will be holding a Presentation and Reception featuring Dr. Dritan Agalliu on Tuesday, June 5, 2012 from 5-8pm.

    You need to RSVP to attend this event by Friday, June 1!

     

    RSVP by calling Andrew DiNuzzo at 949-824-2734.

     

     

     

    From the invitation…

     

    Come visit UC Irvine to view and learn more about the exciting research being done in the lab of Dr. Dritan Agalliu. Dr. Agalliu will explain the mechanisms that break down the blood-brain barrier in PANDAS, and he will show how this knowledge will enable the development of therapies to prevent immune cell or antibody entry into the nervous system, thereby providing long-term treatment for PANDAS.

     

    Dr. Agalliu will host you in the Dean’s office at the UC Irvine School of Biological Sciences, which will be followed by a tour of the Agalliu lab. You will have to opportunity to view, first-hand, his ongoing research. The outlook for prevention and treatment of P.A.N.D.A.S. is getting better each day, so we hope you can join us to learn more about it.

     

    Go to the pdf for more info: http://pandasnetwork.org/wp-content/uploads/2012/05/UCIAdv_PANDAS_InviteFlyer_F.pdf

  2. The State of Connecticut Senate has UNANIMOUSLY passed the bill “AN ACT CONCERNING A STUDY OF PEDIATRIC AUTOIMMUNE NEUROPSYCHIATRIC DISORDER ASSOCIATED WITH STREPTOCOCCAL INFECTIONS”.

     

     

     

     

    This bill requires “The Commissioner of Public Health…to do a study on PANDAS to learn how it’s diagnosed and treated in this country and others and an evaluation of the level of recognition of the disorder in the medical community. The report is to be finished no later than January 1, 2013”.

     

     

     

     

    Further information can be found on the State of CT General Assembly website http://www.cga.ct.gov/asp/cgabillstatus/cgabillstatus.asp?selBillType=Bill&bill_num=SB-0206

     

     

     

     

     

    http://pandasnetwork.org/2012/05/connecticut-passes-bill-for-pandas-research/

  3. The long awaited Tel Aviv has been published! We first heard about this in 2010 and it is finally in print!

     

    Abstract http://www.ncbi.nlm.nih.gov/pubmed/22534626

     

    Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders.

     

    Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D.

     

     

    Source

     

    School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.

     

     

    Abstract

     

    Group A streptococcal (GAS) infections and autoimmunity are associated with the onset of a spectrum of neuropsychiatric disorders in children, with the prototypical disorder being Sydenham chorea (SC). Our aim was to develop an animal model that resembled the behavioral, pharmacological, and immunological abnormalities of SC and other streptococcal-related neuropsychiatric disorders. Male Lewis rats exposed to GAS antigen exhibited motor symptoms (impaired food manipulation and beam walking) and compulsive behavior (increased induced-grooming). These symptoms were alleviated by the D2 blocker haloperidol and the selective serotonin reuptake inhibitor paroxetine, respectively, drugs that are used to treat motor symptoms and compulsions in streptococcal-related neuropsychiatric disorders. Streptococcal exposure resulted in antibody deposition in the striatum, thalamus, and frontal cortex, and concomitant alterations in dopamine and glutamate levels in cortex and basal ganglia, consistent with the known pathophysiology of SC and related neuropsychiatric disorders. Autoantibodies (IgG) of GAS rats reacted with tubulin and caused elevated calcium/calmodulin-dependent protein kinase II signaling in SK-N-SH neuronal cells, as previously found with sera from SC and related neuropsychiatric disorders. Our new animal model translates directly to human disease and led us to discover autoantibodies targeted against dopamine D1 and D2 receptors in the rat model as well as in SC and other streptococcal-related neuropsychiatric disorders.Neuropsychopharmacology advance online publication, 25 April 2012; doi:10.1038/npp.2012.56.

     

     

    PMID: 22534626 [PubMed - as supplied by publisher]

     

     

    http://pandasnetwork.org/2012/04/tel-aviv-study-published/

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