Report Notatum and Naltrexone? in PANS / PANDAS (Lyme included) Posted October 16, 2016 Yes, thru our common dr. I think you can believe in the changes you're seeing. LDN really does help. It hasn't been a cure-all, but definitely supportive and definitely something we'll be keeping on board until DD has come thru the other side of this illness. What's the notatum supposed to do?