Report Cunningham Panel value in PANS / PANDAS (Lyme included) Posted February 18, 2019 @jan251 - What does this "common change" decreasing CamKII and increasing Anti-tubulin mean? We have done the CP twice - first in August 2017 and now Feb 2019. D1 stayed same at 4000, D2 same at 4000, ALgm1 went from 160 to 320, anti-tubulin from 1000 to 2000, the CamKII went from 131 to 113. No one has been able to tell us what this signifies. We have been told that the CP is proof that there is an auto-immune antibody mediated issue. We ordered the 2nd teat to provide current proof in order to request PEX. DS (23) has been under treatment with abx, supplements, paleo diet, and Nsaids for strep and lyme with several co-infections for the past year. Additionally he had tonsils and adenoids removed in Dec 2017 and has had two rounds of HD IVIG - in Aug 2018 and Nov 2018 - no effect. He has eradicated most or all of infectious agents (myco stays high - 800 as do ASO titres 550, but asymptomatic) but still has neuro-psychiatric symptoms of severe anxiety, depression / apathy that seems to wax and wane but is always present. Hew is unable to finish college or hold a job or even interact with people. We are trying to get PEX as we feel we need to remove the existing anti-bodies and then try a few rounds of IVIG to "re-set" immune system. We are waiting to hear if PEX will be approved. WE know IVIG is not - 3 appeals, all denied. Young adults are supposed to be easier to get PEX but we will see. Any insights?