Adults with PANS/PANDAS and CFS? in PANS / PANDAS (Lyme included) Posted September 17, 2019 · Report reply Yes, both of my children, now in their mid to late 20's had PANDAS/PANS, and both have CFS. (They have had the PANDAS since childhood, but it wasn't diagnosed for years and it wasn't a severe problem until they neared purberty.) My son still has severe PANDAS/PANS, but my daughter doesn't have any OCD at all now, although she has many physical issues, including CFS. (She also has Sjogren's Syndrome.) They have both been very physically and neurologically debilitated. All of these immune issues seem to be related.