I too am struggling with this. We were diagnosed less than a week ago. By two separate doctors who said my 6 year olds son was a "classic" example of PANS. I consider myself lucky that I specialize in diagnosing mental health in children that I knew after a few weeks of beyond severe behavioral outbursts, OCD outbreaks, self harming, depression, sensory issues, regressions, etc that something was seriously wrong with my happy, cuddly, people pleaser son who had ZERO behavioral issues before this. When symptoms started we treated them behaviorally which set his anxiety level through the roof making things worse. We started an anti-biotic last week, but because there is no strep and its PANS, the MD and pediatric neurologist haven't wanted to do further blood work to determine what bacteria or virus is causing this. So they started us on what I feel may be a "random" anti-biotic, but now a week later I am searching and weeding through information to tell me what the healing process looks like. Do symptoms completely disappear, do they wax and wane, do some symptoms disappear and some don't, do they just change, does a slow disappearance mean the anti-biotic isn't working on that particular bacteria or does there need to be time for the brain to "heal" once the bacteria is gone (or virus) .. . .its one of the things I am really struggling with myself .. . are things really better because of the anti-biotic or just because we have taken away every expectation for our 6 year old because it leads to violent outbursts, and are handling him like a time bomb constantly. It really makes me feel helpless and confused not knowing what to expect.