Report How low is "low dose" of an ssri? in PANS / PANDAS (Lyme included) Posted April 22, 2016 So non PANS psychiatrist recommended 25mg Zoloft for ds' OCD. Currently treating (or trying to treat) Lyme with abx and supps but would be nice to take the edge off the OCD if possible. I realize it may muddy the waters as to what is working but I owe it to ds to let him try. Hopefully won't regret it. So I believe Dr Swedo or Murphy said 1/10th or 1/4 of a regular dose is a good starting point for pandas/pans kids? Can someone verify?