Report Sleep issues in PANS / PANDAS (Lyme included) Posted August 15, 2012 Dd4 has been doing pretty well, with only a couple of hang-on symptoms. When she was in her bad flare-up a couple of months ago, her sleep cycle got all mixed up with haivng a hard time falling asleep and lots of night waking. With everything else she was doing, it was low on the list of things to tackle at the time It has become a pretty major issue now - she can take over three hours to fall asleep, then still wake up 3-4 times per night and stay awake up to an hour each time. She will come to our bed (which is fine for us), and she will go back to sleep - when she wakes up, she just lays there quiet, but is awake. It doesn't seem to be bad dreams, and she is not complaining of intrusive thoughts - it just seems to be a mixed up sleep/wake cycle. She is getting physically tired, but I'm not sure what to do? We do the whole routine thing, same time every night, etc - but it is not making a dent. A neighbor suggested melatonin? Anyone have success/unsuccessful stories of what they do or what works?