What is the chance of seeing a positive Mycoplasma IgG in the general population? Answer: it depends on age

See Fig 1B in this paper

http://www.ncbi.nlm....df/cd000734.pdf

You find elevated mycoplasma titers in 40% of adolescents in a healthy Finnish population. I'm not sure what the USA numbers are, but they're likely to be similar.

Of course, very few of these people have tics and/or OCD; so it is going to be hard to find an association between elevated mycoplasma IgG and anything.

However, what I'm finding is that patients with PANDAS often have:

1. Peristently elevated ASO, ADB or streptozyme (about 20% chance)

2. Persistently elevated Mycoplasma IgG (about 40% chance)

3. Persistent anti-flagellin (p41 IgG and IgM) - probably no more than 20% chance

The chance of having all three together - probably no more than 5%. So, the proper study would be to look at multiple co-infections, not just one, to prove association. You would need an enormously large population to prove association with any one alone.

MY GUESS:

So what is the common thread here? : strep, mycoplasma and Lyme all have tendencies to be

**persistent**illnesses, i.e. in some people there is difficulty clearing them from the body. There is a progressive accumulation of peristent bacterial illness, individually subclinical but together, problematic. All signaling through a common TLR (toll-like receptor) mechanism producing abnormal cytokines and ultimately PANDAS like symptoms.

P.S. These are just my ideas, not reality. But you gotta have hypotheses or there are no answers - that just how science works.

Dr. T