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Resveratrol


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9 replies to this topic

#1 rowingmom

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Posted 27 February 2012 - 02:47 PM

I have noticed resveratrol mentioned several times lately. We use a supplement derived from and containing Japanese knotweed, others may be made from red wine grapes, but which do not contain the herb Japanese knotweed. An excerpt from Healing Lyme – Natural Healing and Prevention of Lyme Borreliosis and Its Coinfections (Stephen Buhner):

Japanese Knotweed (Polygonum cuspidatum)

A broadly systemic plant, Japanese knotweed modulates and enhances immune function, is active against a number of gram-negative and gram-positive bacteria including leptospira and Treponema denticola spirochetes, is anti-inflammatory for both arthritic and bacterial inflammations, protects the body against endotoxin damage, helps reduce Herxheimer reactions, and is a cardioprotector.. …While there are a number of herbs that can reduce autoinflammatory conditions stimulated by MMP-1 and -3 (e.g. curcumin), the only herb that specifically blocks MMP-1 and MMP-3 induction through these …particular pathways is Polygonum cuspidatum. Resveratrol (one of the plant’s constitutents) is also directly active in reducing MMP-9 levels through both the JNK and protein kinase C-delta pathways; it has been found to specifically inhibit MMP-9 gene transcription….Polygonum cuspidatum’s constituents cross the BBB where they exert actions on the central nervous system….The herb specifically protects the brain from inflammatory damage, microbial endotoxins, and bacterial infections…..Knot weed enhances blood flow especially to the eye, heart, skin, and joints….it is also specific for treating bartonella coinfections that can occur in Lyme disease….It should be stressed that while resveratrol does do amazing things, it, by itself, is not sufficient in treating Lyme disease. The whole herb is crucial. Other constituents of the plant, such as emodin, polydatin, and trans-resveratrol have all been found to be “wonderdrugs” in their own right. The herb is also broadly antifungal (part of resveratrol’s function in the plant). It is strongly inhibitive against Candida albicans. …. Japanese knotweed is an angiogenesis modulator. That is, it stimulates the formation of new blood vessels and the healing of damaged ones in areas such as burned skin. But it also stops the development of new vessels and blood flow in areas where it should not occur, such as in malignant and benign tumor formation….It has…specific modulating and protectant actions on the endothelial cells that line blood vessels. (This is important for bartonella infections – my addition).

I'm not sure if the resveratrol supplements derived from grapes would have the same effect on lyme and co. that P. cuspidatum does. Buhner does not think so. I have not tried it, but my daughter and I both notice a difference in the way we feel with the Japanese knotweed. Buhner's book is a great reference for anyone wanting to use herbal supplementation.

DD13 - Born 2001 with light/sound/touch sensitivity. Loss of speech/fine motor ability 2 weeks after 15 month MMR vaccination.
2004 - Dx ADHD, sensory disorder (light, sound, touch), motor delay (with toe-walking), hypotonia, oral apraxia.
2008 - MMR booster and insect bite (bruise-like rash) - motor/vocal tics, emotional lability (including rage), age regressive behaviour, low level OCD, urinary frequency, diminished fine motor ability, insomnia, loss of executive function. Waxed and waned with strep/viral infections.
2010 - Dx ADHD, Tourettes, Aspergers, motor delay, probable PANDAS.
Jan 2011 - shin/forearm pain, cyclic IBS, foot (sole) pain, dizziness, palpitations, chest pain, anxiety/panic attacks, pick-like skull pain, pain and stiffness at base of skull, tingling in extremeties, chills and hot flashes, extreme fatigue, nightly fever. 
June 2011 - Igenex PCR positive bartonella, Negative ELISA, Negative lyme (IND IgM kDa 41; IND IgG kDa 39, 34.  kDa 41++). CD57 18.  Positive ANA (speckled type), heterozygous A1298C MTHFR. Multiple Abx, methyl B12, methylfolate, P-5-P, herbal, homeopathic treatment with LLMD.

Jan 2013 - Bartonella IgG titers declined from 160 (Jun 2011) to 80.  CD57 16. 

April 2013 - Weaned from abx treatment at 80% improvement.  Continued with Full Buhner bartonella herbal protocol, Terry Wahls/PerfectHealthDiet gf/cf/sf diet.  Minimizing EMF exposure.

Sept 2013 - CD57 45.  

Oct 2013 - All symptoms (PANS and pain/fatigue) 95% resolved.  No flares with viral or other infections.  Herxing remains with changes in herbal protocols.

Nov 2013 - Improvement to 98% with addition of Buhner herbal protozoan treatment.

Dec 2013 - ANA titers negative.  PANS symptoms resolved.  Regular classroom requiring no accommodations.  B+/A student.

Mar 2014 - Continued improvement in cognitive/executive function with increased dosages of cryptolepis/sida/alchornea (CSA) tincture.

Sept 2014 - Continued improvement with the addition of red root and bidens.  Resolution of EMF sensitivities with low dose cilantro tincture.  99%         

DS17 - Born 1996. No unusual symptoms.



#2 llm

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Posted 27 February 2012 - 03:26 PM

This is great info. I tried to pin it under helpful threads but royally screwed it up. All cylinders not firing tonight. Perhaps someone else can?

#3 jjl

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Posted 27 February 2012 - 04:26 PM

Thank you for this information. Sounds very promising. Can you tell me what brand and where you purchase this herb? I appreciate it, John L



I have noticed resveratrol mentioned several times lately. We use a supplement derived from and containing Japanese knotweed, others may be made from red wine grapes, but which do not contain the herb Japanese knotweed. An excerpt from Healing Lyme – Natural Healing and Prevention of Lyme Borreliosis and Its Coinfections (Stephen Buhner):

Japanese Knotweed (Polygonum cuspidatum)

A broadly systemic plant, Japanese knotweed modulates and enhances immune function, is active against a number of gram-negative and gram-positive bacteria including leptospira and Treponema denticola spirochetes, is anti-inflammatory for both arthritic and bacterial inflammations, protects the body against endotoxin damage, helps reduce Herxheimer reactions, and is a cardioprotector.. …While there are a number of herbs that can reduce autoinflammatory conditions stimulated by MMP-1 and -3 (e.g. curcumin), the only herb that specifically blocks MMP-1 and MMP-3 induction through these …particular pathways is Polygonum cuspidatum. Resveratrol (one of the plant’s constitutents) is also directly active in reducing MMP-9 levels through both the JNK and protein kinase C-delta pathways; it has been found to specifically inhibit MMP-9 gene transcription….Polygonum cuspidatum’s constituents cross the BBB where they exert actions on the central nervous system….The herb specifically protects the brain from inflammatory damage, microbial endotoxins, and bacterial infections…..Knot weed enhances blood flow especially to the eye, heart, skin, and joints….it is also specific for treating bartonella coinfections that can occur in Lyme disease….It should be stressed that while resveratrol does do amazing things, it, by itself, is not sufficient in treating Lyme disease. The whole herb is crucial. Other constituents of the plant, such as emodin, polydatin, and trans-resveratrol have all been found to be “wonderdrugs” in their own right. The herb is also broadly antifungal (part of resveratrol’s function in the plant). It is strongly inhibitive against Candida albicans. …. Japanese knotweed is an angiogenesis modulator. That is, it stimulates the formation of new blood vessels and the healing of damaged ones in areas such as burned skin. But it also stops the development of new vessels and blood flow in areas where it should not occur, such as in malignant and benign tumor formation….It has…specific modulating and protectant actions on the endothelial cells that line blood vessels. (This is important for bartonella infections – my addition).

I'm not sure if the resveratrol supplements derived from grapes would have the same effect on lyme and co. that P. cuspidatum does. Buhner does not think so. I have not tried it, but my daughter and I both notice a difference in the way we feel with the Japanese knotweed. Buhner's book is a great reference for anyone wanting to use herbal supplementation.



#4 rowingmom

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Posted 27 February 2012 - 06:21 PM

We use Source Naturals brand 500 mg tablets from i-Herb. Source Naturals has a couple of different types of Resveratrol. One is derived from Knotweed, and the other has resveratrol from grapes. We use the knotweed derived. Buhner used to suggest this source, but now he recommends 450 mg capsules, wild-crafted from Green Dragon Botanicals. All the sources for the herbs he recommends, as well as the maximum dosages for the herbs in his core protocol, can be found on his website:

http://buhnerhealinglyme.com

He will also answer submitted questions, or you can search the site for info specific to each herb or coinfection.

My daughter and I both use 500mg TID, the same with cat’s claw. His maximum dosages exceed this by quite a bit. I made the mistake last week of doubling my dosage of cat’s claw (got Source Naturals instead of Nature’s Way – it was on sale and I thought, what the heck it couldn’t make that much difference). I was brain fogged, confused and raging in 4 days – my poor husband. I haven’t felt that bad for years. It took me half the day to figure out what I had done to myself. A couple of Epsom salt baths and two days later (and back to the lower dose), I’m fine. Silly me. Ramp up slowly. At least I didn't try that on DD.

Edited by rowingmom, 27 February 2012 - 06:22 PM.

DD13 - Born 2001 with light/sound/touch sensitivity. Loss of speech/fine motor ability 2 weeks after 15 month MMR vaccination.
2004 - Dx ADHD, sensory disorder (light, sound, touch), motor delay (with toe-walking), hypotonia, oral apraxia.
2008 - MMR booster and insect bite (bruise-like rash) - motor/vocal tics, emotional lability (including rage), age regressive behaviour, low level OCD, urinary frequency, diminished fine motor ability, insomnia, loss of executive function. Waxed and waned with strep/viral infections.
2010 - Dx ADHD, Tourettes, Aspergers, motor delay, probable PANDAS.
Jan 2011 - shin/forearm pain, cyclic IBS, foot (sole) pain, dizziness, palpitations, chest pain, anxiety/panic attacks, pick-like skull pain, pain and stiffness at base of skull, tingling in extremeties, chills and hot flashes, extreme fatigue, nightly fever. 
June 2011 - Igenex PCR positive bartonella, Negative ELISA, Negative lyme (IND IgM kDa 41; IND IgG kDa 39, 34.  kDa 41++). CD57 18.  Positive ANA (speckled type), heterozygous A1298C MTHFR. Multiple Abx, methyl B12, methylfolate, P-5-P, herbal, homeopathic treatment with LLMD.

Jan 2013 - Bartonella IgG titers declined from 160 (Jun 2011) to 80.  CD57 16. 

April 2013 - Weaned from abx treatment at 80% improvement.  Continued with Full Buhner bartonella herbal protocol, Terry Wahls/PerfectHealthDiet gf/cf/sf diet.  Minimizing EMF exposure.

Sept 2013 - CD57 45.  

Oct 2013 - All symptoms (PANS and pain/fatigue) 95% resolved.  No flares with viral or other infections.  Herxing remains with changes in herbal protocols.

Nov 2013 - Improvement to 98% with addition of Buhner herbal protozoan treatment.

Dec 2013 - ANA titers negative.  PANS symptoms resolved.  Regular classroom requiring no accommodations.  B+/A student.

Mar 2014 - Continued improvement in cognitive/executive function with increased dosages of cryptolepis/sida/alchornea (CSA) tincture.

Sept 2014 - Continued improvement with the addition of red root and bidens.  Resolution of EMF sensitivities with low dose cilantro tincture.  99%         

DS17 - Born 1996. No unusual symptoms.


#5 michaeltampa

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Posted 28 February 2012 - 02:03 PM

Buhner certainly leans toward the whole plant kind of supplements and is a fan of japanese knotweed. I want to point out I have found Country Life's "Resveratrol Plus" supplement by far the best for me in terms of herbs in the knotweed/resveratrol category. This product contains a combination of whole herb and concentrated resveratrol from 4 different sources (one of them japanese knotweed)

#6 rowingmom

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Posted 28 February 2012 - 06:15 PM

Buhner certainly leans toward the whole plant kind of supplements and is a fan of japanese knotweed. I want to point out I have found Country Life's "Resveratrol Plus" supplement by far the best for me in terms of herbs in the knotweed/resveratrol category. This product contains a combination of whole herb and concentrated resveratrol from 4 different sources (one of them japanese knotweed)

Thanks, we will give that a try.

DD13 - Born 2001 with light/sound/touch sensitivity. Loss of speech/fine motor ability 2 weeks after 15 month MMR vaccination.
2004 - Dx ADHD, sensory disorder (light, sound, touch), motor delay (with toe-walking), hypotonia, oral apraxia.
2008 - MMR booster and insect bite (bruise-like rash) - motor/vocal tics, emotional lability (including rage), age regressive behaviour, low level OCD, urinary frequency, diminished fine motor ability, insomnia, loss of executive function. Waxed and waned with strep/viral infections.
2010 - Dx ADHD, Tourettes, Aspergers, motor delay, probable PANDAS.
Jan 2011 - shin/forearm pain, cyclic IBS, foot (sole) pain, dizziness, palpitations, chest pain, anxiety/panic attacks, pick-like skull pain, pain and stiffness at base of skull, tingling in extremeties, chills and hot flashes, extreme fatigue, nightly fever. 
June 2011 - Igenex PCR positive bartonella, Negative ELISA, Negative lyme (IND IgM kDa 41; IND IgG kDa 39, 34.  kDa 41++). CD57 18.  Positive ANA (speckled type), heterozygous A1298C MTHFR. Multiple Abx, methyl B12, methylfolate, P-5-P, herbal, homeopathic treatment with LLMD.

Jan 2013 - Bartonella IgG titers declined from 160 (Jun 2011) to 80.  CD57 16. 

April 2013 - Weaned from abx treatment at 80% improvement.  Continued with Full Buhner bartonella herbal protocol, Terry Wahls/PerfectHealthDiet gf/cf/sf diet.  Minimizing EMF exposure.

Sept 2013 - CD57 45.  

Oct 2013 - All symptoms (PANS and pain/fatigue) 95% resolved.  No flares with viral or other infections.  Herxing remains with changes in herbal protocols.

Nov 2013 - Improvement to 98% with addition of Buhner herbal protozoan treatment.

Dec 2013 - ANA titers negative.  PANS symptoms resolved.  Regular classroom requiring no accommodations.  B+/A student.

Mar 2014 - Continued improvement in cognitive/executive function with increased dosages of cryptolepis/sida/alchornea (CSA) tincture.

Sept 2014 - Continued improvement with the addition of red root and bidens.  Resolution of EMF sensitivities with low dose cilantro tincture.  99%         

DS17 - Born 1996. No unusual symptoms.


#7 hopeny

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Posted 05 March 2012 - 07:50 PM

Are you familiar with revgenetics.com reseveratrol? I have used before and I am convinced it helped me conceive a healthy baby at 40. I saw this thread and was interested. My 8 y.o. has Lyme and I am looking for ways to help her. What is the children's dosage? Thanks

#8 rowingmom

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Posted 06 March 2012 - 04:57 AM

Are you familiar with revgenetics.com reseveratrol? I have used before and I am convinced it helped me conceive a healthy baby at 40. I saw this thread and was interested. My 8 y.o. has Lyme and I am looking for ways to help her. What is the children's dosage? Thanks


The dosages are listed on the left hand side of the front page of the website:

http://buhnerhealinglyme.com/

I have not tried revgenetics

DD13 - Born 2001 with light/sound/touch sensitivity. Loss of speech/fine motor ability 2 weeks after 15 month MMR vaccination.
2004 - Dx ADHD, sensory disorder (light, sound, touch), motor delay (with toe-walking), hypotonia, oral apraxia.
2008 - MMR booster and insect bite (bruise-like rash) - motor/vocal tics, emotional lability (including rage), age regressive behaviour, low level OCD, urinary frequency, diminished fine motor ability, insomnia, loss of executive function. Waxed and waned with strep/viral infections.
2010 - Dx ADHD, Tourettes, Aspergers, motor delay, probable PANDAS.
Jan 2011 - shin/forearm pain, cyclic IBS, foot (sole) pain, dizziness, palpitations, chest pain, anxiety/panic attacks, pick-like skull pain, pain and stiffness at base of skull, tingling in extremeties, chills and hot flashes, extreme fatigue, nightly fever. 
June 2011 - Igenex PCR positive bartonella, Negative ELISA, Negative lyme (IND IgM kDa 41; IND IgG kDa 39, 34.  kDa 41++). CD57 18.  Positive ANA (speckled type), heterozygous A1298C MTHFR. Multiple Abx, methyl B12, methylfolate, P-5-P, herbal, homeopathic treatment with LLMD.

Jan 2013 - Bartonella IgG titers declined from 160 (Jun 2011) to 80.  CD57 16. 

April 2013 - Weaned from abx treatment at 80% improvement.  Continued with Full Buhner bartonella herbal protocol, Terry Wahls/PerfectHealthDiet gf/cf/sf diet.  Minimizing EMF exposure.

Sept 2013 - CD57 45.  

Oct 2013 - All symptoms (PANS and pain/fatigue) 95% resolved.  No flares with viral or other infections.  Herxing remains with changes in herbal protocols.

Nov 2013 - Improvement to 98% with addition of Buhner herbal protozoan treatment.

Dec 2013 - ANA titers negative.  PANS symptoms resolved.  Regular classroom requiring no accommodations.  B+/A student.

Mar 2014 - Continued improvement in cognitive/executive function with increased dosages of cryptolepis/sida/alchornea (CSA) tincture.

Sept 2014 - Continued improvement with the addition of red root and bidens.  Resolution of EMF sensitivities with low dose cilantro tincture.  99%         

DS17 - Born 1996. No unusual symptoms.


#9 hopeny

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Posted 06 March 2012 - 08:36 PM


Are you familiar with revgenetics.com reseveratrol? I have used before and I am convinced it helped me conceive a healthy baby at 40. I saw this thread and was interested. My 8 y.o. has Lyme and I am looking for ways to help her. What is the children's dosage? Thanks


The dosages are listed on the left hand side of the front page of the website:

http://buhnerhealinglyme.com/

I have not tried revgenetics


thank you, I am going to start her on it

#10 hopeny

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Posted 06 March 2012 - 08:39 PM


Are you familiar with revgenetics.com reseveratrol? I have used before and I am convinced it helped me conceive a healthy baby at 40. I saw this thread and was interested. My 8 y.o. has Lyme and I am looking for ways to help her. What is the children's dosage? Thanks


The dosages are listed on the left hand side of the front page of the website:

http://buhnerhealinglyme.com/

I have not tried revgenetics


thank you, I am going to start her on it




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