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Mycoplasma IVIG


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Thanks so much for your input tpotter. However, if IVIG does in fact reboot, so to say wouldn't it make the immune system no longer react to the mycoplasma in that way if you do IVIG enough times? Isn't the whole theory behind PANDAS a sort of resistant form of strep, but IVIG puts things into remission. Im quite lost with the whole idea of chronic infections.

 

 

If your child's MYcoplasma IgM is elevated- it is not chronic I wouldn't think- it would be active. IgG elevated would lend itsef more to chronic or gone.I would say treat for an active infection so it does not go chronic or dormant.

 

The theory behind PANDAS, from my understadning is not a resistant form of Strep- rather that antibodies that were formed to Strep crossed the blood brain barrier and set up housekeeping in the basa ganglia. The antibodies are what "react" with a recurrent Strep infection that cause the neuropsychiatric symptoms. Neuroinflammation- high Camkinase II- having a party in the basal ganglia whenever child gets exposed to Strep or other offending triggering bug.

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  • 3 years later...
  • 3 years later...
On 1/3/2012 at 4:55 PM, Dedee said:

Hi Lauren,

 

I have 3 PANS children. One is reactive only to strep and the other two we discovered this past year were positive for Myco p. Both of the younger ones have had pneumonia in the past but were not showing any signs of active respiratory infection at the time we got the positive titers. We had both elevated IgG and IgM titers. I am sure you will do your homework and read plenty on myco p. but the basic is that it is a very difficult bug to get rid of because of it's ability to "hide out" in a somewhat dormant phase and replacate. Some physicians refer to it as a cross between a virus and a bacteria. Myco may take many months or sometimes up to two years to clear completely. Some children will have Mycoplasma and never have neuropsych symptoms. Other children, such as ours, are triggered by the mycoplasma causing an autoimmune reaction and the chain reaction that occurs with PANS children. The IVIG is not given to treat the bacterial infection. It is given to stop the autoimmune reaction and the inflammatory reaction(in the brain) that causes the neuropsychiatric symptoms. Also, it helps strengthen the immune system and (hopefully) decreasing future flares or a least the severity. However, IVIG will not be effective if the infectious process has not been addressed. So it is important to get a good grip on finding the appropriate antibiotic that will work for your child. Seems that every child reacts differently. There are many different species of mycoplasma bacteria. Therefore different children will react differently to treatment depending on which species they are infected with. Testing to differentiate myco species is very expensive and not normally done as part of the treatment. They start with the most common antibiotic and treat by results. We started with Zithromax and saw little effect after one month, so we switched to Biaxin and saw huge improvement in days. The improvement halted after a while and so we switched to Erythramycin. It is important to see a physician who has experience treating mycoplasma. Our current provider believes we still have residual inflammation and we are going to do a round of IV clindamycin with oral Minocycline starting next week. Minocycline is also a good antibiotic for myco because it is an antinflammatory and also opens the blood brain barrier. Some doctors use it in combination with Zitromax or another antibiotic.

 

I know you are upset that you have this to deal with but it is better to know who the enemy is so to speak so you can address it head on. Once you get the appropriate antibiotic I believe you will start to see great improvement. Best of luck.

 

Dedee

Hi Dedee. An updates on your kids now years later? I learned so much from your posts and would love to find out if they are symptom free and myco free now?

thanks!

 

Sophia

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